Results 101 to 110 of about 4,551,617 (315)

Research on Optimal Attitude of Large Deformation Airplane in Full‑Scale Aircraft Static Test

open access: yesTransactions of Nanjing University of Aeronautics and Astronautics
The accuracy of the full-scale aircraft static tests is greatly influenced by the aircraft attitude. This paper proposes an aircraft attitude optimization method based on the characteristics of the test.
ZHENG Jianjun   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Experimental investigation of an ejector-powered free-jet facility [PDF]

open access: yes
NASA Lewis Research Center's (LeRC) newly developed Nozzle Acoustic Test Rig (NATR) is a large free-jet test facility powered by an ejector system.
Long, Mary JO
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Testing of aircraft passenger seat cushion materials. Full scale, test description and results, volume 1 [PDF]

open access: yes
Eight different seat cushion configurations were subjected to full-scale burn tests. Each cushion configuration was tested twice for a total of sixteen tests. Two different fire sources were used. They consisted of one liter of Jet A fuel for eight tests
Duskin, F. E.   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Laboratory testing of full scale lifeboat: pendulum tests

open access: yes, 2010
A set of experiments were designed and conducted using a modified 20-person TEMPSC. The experiments involved suspending ice spheres from a line acting as a pendulum. Thesphere was then set at a specified angle, and allowed to freefall in the pendulum’s naturalarc until impact with the panel.
openaire   +2 more sources

Abradable compressor and turbine seals, volume 1 [PDF]

open access: yes
The application and advantages of abradable coatings as gas-path seals in a general aviation turbine engine were evaluated for use on the high-pressure compressor, the high-pressure turbine, and the low-pressure turbine shrouds.
Dennis, R. E.   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Home - About - Disclaimer - Privacy