Results 101 to 110 of about 1,492,497 (311)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Full-Scale Bollard Pull Trials With CCGS Sir John Franklin

open access: yes, 1990
Bollard pull trials were conducted aboard CCGS Sir John Franklin on January 23, 1990 in Marystown (Cow Head), Newfoundland. These trials were part one of a three phase test program with a primary objective to obtain full-scale correlation for the ice and
Hackett, P. J.   +3 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Research on Optimal Attitude of Large Deformation Airplane in Full‑Scale Aircraft Static Test

open access: yesTransactions of Nanjing University of Aeronautics and Astronautics
The accuracy of the full-scale aircraft static tests is greatly influenced by the aircraft attitude. This paper proposes an aircraft attitude optimization method based on the characteristics of the test.
ZHENG Jianjun   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Power Minimisation Techniques for Testing Low Power VLSI Circuits (PhD Dissertation)

open access: yes, 2000
Testing low power very large scale integrated (VLSI) circuits has recently become an area of concern due to yield and reliability problems. This dissertation focuses on minimising power dissipation during test application at logic level and register ...
Nicolici, N.
core  

International Full-Scale Test Facility for Structural Control [PDF]

open access: yes, 1994
Planning is underway to establish an international full-scale test facility for structural control on the campus of the Hong Kong University of Science and Technology.
Beck, James L.   +2 more
core  

Model-scale/full-scale correlation of OCRE's model test results in supporting the CCGS Polar Icebreaker model test data evaluation

open access: yes, 2012
This document gives a summary of the model-scale/full-scale correlation performed on model test data generated at the National Research Council Ocean, Coastal, and River Engineering (NRC-OCRE) test facility in St. John\u2019s in support of the evaluation
Lau, Michael, Wang, Jungyong
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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