Results 31 to 40 of about 3,547 (202)
Frontiers in Microbiology, 2020 Nosema ceranae infections in honey bees (Apis mellifera) pose a severe threat to colony health. Beekeepers have used dicyclohexylammonium fumagillin to control Nosema apis, although it may be ineffective against N. ceranae. We investigated the ability of
Andre J. Burnham +8 more
doaj +1 more source
The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. [PDF]
PLoS ONE, 2013 Aspergillus fumigatus is the causative agent of invasive aspergillosis, leading to infection-related mortality in immunocompromised patients. We previously showed that the conserved and unique-to-fungi veA gene affects different cell processes such as ...
Sourabh Dhingra +5 more
doaj +1 more source
Plants, 2023 Mycotoxins are one of the most important sources for the discovery of new pesticides and drugs because of their chemical structural diversity and fascinating bioactivity as well as unique novel targets.
Jiale Shi +10 more
doaj +1 more source
Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery [PDF]
, 2015 Sn2 lipase labile phospholipid prodrugs in conjunction with contact-facilitated drug delivery offer an important advancement in Nanomedicine. Many drugs incorporated into nanosystems, targeted or not, are substantially lost during circulation to the ...
Abes +103 more
core +2 more sources
Syntheses of Fumagillin and Ovalicin [PDF]
Chemistry – A European Journal, 2010 AbstractThis review focuses on the synthetic strategies used for the construction of fumagillin, ovalicin, and other natural products of this family that are known angiogenesis inhibitors. These compounds are comprised of a cyclohexane framework, two epoxides, and five or six contiguous stereogenic centers.
Junichiro, Yamaguchi, Yujiro, Hayashi
openaire +2 more sources
Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors [PDF]
, 2014 Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses.
Alberto Coego +81 more
core +5 more sources
Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice. [PDF]
PLoS ONE, 2018 Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions.
Isabel Pont +7 more
doaj +1 more source
Microorganisms, 2021 Nosema ceranae (Opisthosporidia: Microsporidia) is an emergent intracellular parasite of the European honey bee (Apis mellifera) and causes serious Nosema disease which has been associated with worldwide honey bee colony losses.
Nan He +8 more
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Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the Brown Norway rat [PDF]
, 2017 Although angiogenesis is a hallmark feature of asthmatic inflammatory responses, therapeutic anti-angiogenesis interventions have received little attention. Objective: Assess the effectiveness of anti-angiogenic Sn2 lipase-labile prodrugs delivered via α(
Allen, John S +16 more
core +2 more sources
Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin
Emerging Infectious Diseases, 2017 Enterocytozoon bieneusi microsporidiosis is an emerging disease in immunocompromised patients. We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. Thrombocytopenia occurred but
Iryna Bukreyeva +9 more
doaj +1 more source