Results 101 to 110 of about 2,275 (253)

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited.
Nicholas Belviso, Sarah F Wesley, Sai L Shankar, James B Lewin, Erin E Longbrake, John Scagnelli, Lynsey L Lakin, Boyang Bian, Ahmed Z Obeidat, Mirla Avila, Kyle Smoot, Afif Hentati, Jason P Mendoza, William Meador, Mark Gudesblatt   +14 more
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A series of new lanthanide fumarates displaying three types of 3-D frameworks

A series of lanthanide fumarates [Sm2(fum)3(H2fum)(H2O)2] (1, H2fum = fumaric acid), [Ln2(fum)3- (H2O)4]·3H2O {Ln = Tb (2a), Dy (2b)} and [Ln2(fum)3(H2O)4] {Ln = Y (3a), Ho (3b), Er (3c), Tm (3d)} were prepared by the hydrothermal method and their ...
Fu, Lianshe, Zhou, Jian, Tan, Xiao-Feng, Zou, Hua Hong, Xiao, Hong-Ping, Xiao, Hong Ping, Zou, Hua-Hong, Tang, Qiuling, Tan, Xiao Feng   +8 more
core   +1 more source

Autoimmune skin diseases in multiple sclerosis

Neurology Perspectives
Introduction: Autoimmune dermatological diseases have a prevalence greater than 2% in the general population, sometimes as a primary disorder and other times within a context of systemic involvement.
M. Roncero Riesco, A. Cabanillas Cabral, Y. El Berdei Montero   +2 more
doaj   +1 more source

The molar kerr constants, dipole moments, and relaxation times of Methyl and Ethyl Maleates and fumarates, Ethyl Formate, Diethyl Oxalate, and of Ethyl and Propyl Azodiformates

, 1957
Values for the properties and compounds named in the title are recorded at infinite dilution in carbon tetrachloride at 25 C. Dipole moments of the seven diesters lie between 2 2 and 2.8 D ; the molar Kerr constants of the two azodiformates however ...
CG Le Fevre, WT Oh, RJW Le Fevre
core   +1 more source

Fumaric acid esters in the management of psoriasis

Psoriasis: Targets and Therapy, 2015
Deepak MW Balak Department of Dermatology, Erasmus Medical Center, Rotterdam, the Netherlands Abstract: Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic
Balak DMW
doaj  

Fumarate [PDF]

Trends in Endocrinology & Metabolism
Désirée Schatton, Christian Frezza
openaire   +2 more sources

Polymerization of Unsaturated Dibasic Acid Derivatives (III) Synthe~es and Polymerization of Alkyl Viny Maleates and Fumarates [PDF]

Ethyl-,n-propyl-, i-propyl and n-butyl vinyl maleates and fumarates were synthesised by the vinyl interchange reaction of vinyl acetate with mono alkyl maleates,a nd the physical properties of these compounds were determined.
高瀬, 巌, 山田, 正盛, YAMADA, Masamori, TAKASE, Iwao   +3 more
core  

Synthesis of Chromeno[4′,3′:4,5]pyrido[1,2-a]pyrazines and -diazepines by the Reaction of Substituted 2-(3-Acetyl-2-oxo-2H-chromen-4-yl)fumarates with 1,n-Diamines

, 2018
A two-step sequence was developed for the synthesis of chromeno[4′,3′:4,5]pyrido[1,2-a]pyrazine-13-carboxylates and -diazepine-14-carboxylates by the reaction of substituted dimethyl 2-(3-acetyl-2-oxo-2H-chromen-4-yl)fumarates with 1,n-diamines at room ...
Abdolali Alizadeh, Parinaz Jamal
core   +1 more source