Results 161 to 170 of about 2,909 (219)

Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study. [PDF]

Mult Scler
Yaldizli Ö, Benkert P, Achtnichts L, Bar-Or A, Bohner-Lang V, Bridel C, Comabella M, Findling O, Disanto G, Finkener S, Gobbi C, Granziera C, Herwerth M, Hoepner R, Horakova D, Kamber N, Khalil M, Kunz P, Lalive P, Linker R, Lorscheider J, Müller S, Oechtering J, Pettypool V, Piehl F, Pot C, Roth P, Théaudin M, Tintore M, Tur C, Uffer D, Uginet M, Vehoff J, Wiendl H, Ziemssen T, Zecca C, Salmen A, Leppert D, Derfuss T, Derfuss T, Kappos L, Hemkens LG, Janiaud P, Kuhle J.   +43 more
europepmc   +1 more source

Optimised Sample Preparation for Metabolic Analysis of Cell Cultures Using DESI‐MS

Chemistry–Methods, Volume 6, Issue 4, April 2026.
Cell pellets are washed once with a 1:1 PBS/AA mixed solution for desalting and pipetted directly onto a reversed‐phase TLC slide as discrete spots and then analysed by desorption electrospray ionisation mass spectrometry imaging (DESI‐MSI). The same slide can be re‐measured for different mass ranges/acquisition modes, enabling comprehensive targeted ...
Wei Chen, Chiara Urban, Hakan Taskiran, Chenyue Dai, Kıvanç Görgülü, Julia Jellusova, Nicole Strittmatter   +6 more
wiley   +1 more source

The Evolving Role of Monomethyl Fumarate Treatment as Pharmacotherapy for Relapsing-Remitting Multiple Sclerosis. [PDF]

Cureus
Kaye AD, Lacey J, Le V, Fazal A, Boggio NA, Askins DH, Anderson L, Robinson CL, Paladini A, Mosieri CN, Kaye AM, Ahmadzadeh S, Shekoohi S, Varrassi G.   +13 more
europepmc   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

Safety and Efficacy of COVID-19 Vaccines Among Patients with Multiple Sclerosis: Letter to Editor. [PDF]

Int J Prev Med
Mirmosayyeb O, Ghaffary EM, Zabeti A, Shaygannejad V.   +3 more
europepmc   +1 more source

Recent Developments in the Field of Air‐Stable Nickel(0) Precatalysts for Cross‐Coupling Reactions

European Journal of Inorganic Chemistry, Volume 29, Issue 10, 1 April 2026.
The development of bench‐stable Ni(0) sources aims to replace air‐sensitive [Ni(COD)2] (cod = cycloocta‐1,5‐diene) with easy‐to‐handle alternatives. Through a targeted ligand design, using electron‐deficient dienes, carbenes, and fluorophosphines, researchers have achieved air‐ and moisture‐tolerant complexes that show high catalytic activity in cross ...
Franziska Flecken, Schirin Hanf
wiley   +1 more source

Retinal neuronal loss and progression independent of relapse activity in multiple sclerosis. [PDF]

J Neurol
Burguet Villena F, Cerdá-Fuertes N, Hofer L, Schädelin S, Sellathurai S, Schoenholzer K, D'Souza M, Oechtering J, Hanssen H, Gugleta K, Cagol A, Granziera C, Kappos L, Petzold A, Benkert P, Kuhle J, Papadopoulou A.   +16 more
europepmc   +1 more source

From Immunization to Autoimmunity: A Deep Dive Into Post‐COVID‐19 Vaccine Reactions—A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Coronavirus disease‐2019 (COVID‐19) emerged in 2019 from Wuhan, China, leading to the accelerated development of vaccines, which have proven instrumental in controlling the spread of the virus. While vaccination ceased the increasing trend of the viral infection, rare adverse autoimmune events emerged as important ...
Mohammad Javad Yousefi‐Hashemabad, Saeed Hashemi, Kiarash Saleki, Seyed Mohamad Kazem Nourbakhsh, Andia Saleki, Zahra Hassanzadeh, Abbas Azadmehr   +6 more
wiley   +1 more source

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature. [PDF]

Turk J Biol
Yilmaz M, Sever B, Kutlu Y, Gül M, Okuducu C, Tavli S, Otsuka M, Fujita M, Haliloğlu T, Çiftçi H, Demirci H.   +10 more
europepmc   +1 more source