Results 181 to 190 of about 2,275 (253)

Pharmacological Modulation of Nrf2 Signaling Regulates Oxidative Stress, Inflammation, and Alveolar Bone Loss in Experimental Periodontitis

Journal of Periodontal Research, EarlyView.
Pharmacological activation of Nrf2 attenuated alveolar bone loss and protected periodontal tissues by reducing inflammation and oxidative stress, preserving collagen organization, and favoring bone homeostasis. Reversal of these effects by Nrf2 inhibition further supports Nrf2 signaling as a promising therapeutic target in periodontitis.
Vitória Bonan Costa, Mariely Araújo de Godoi, Angelo Constantino Camilli, Isabela Rinaldi Gomes Nogueira, Veronica Canela Estevam dos Santos, Lucas Nogueira Ramos, Juliana Silva Siqueira, Camila Renata Corrêa Camacho, Morgana Rodrigues Guimarães Stabili   +8 more
wiley   +1 more source

Comparative Effectiveness and Risk of Severe Infection in Adult Patients With MS Treated With Diroximel Fumarate Versus Anti-CD20 Monoclonal Antibodies: A Real-World Claims Analysis. [PDF]

Adv Ther
Obeidat AZ, Betz M, Farber RS, Goff E, Gudesblatt M, Hua LH, Mao-Draayer Y, Robertson D, Santoro JD, Wang T, Gomes D, Bozin I, Mendoza JP, Bian B, Lewin JB, Belviso N, Shankar SL.   +16 more
europepmc   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

A Wild Emmer Wheat B3 Transcription Factor Regulates Seed Growth and Nutrient Allocation

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed weight (SW) and nutrient allocation are key determinants of yield and grain quality in wheat, yet the regulatory basis of naturally occurring variation in these traits remains poorly resolved. Wild emmer wheat (Triticum dicoccoides), the progenitor of modern wheat, retains extensive eco‐geographically structured genetic diversity that was
Davinder Sharma, Zechariah Haber, Manas R. Prusty, Raz Avni, Mijal Perez, Moshe Ronen, Rakesh Kumar, Arava Shatil‐Cohen, Paz Haboub, Chen Omer, Gilor Kelly, Hadar Aviv, Adi Doron‐Faigenboim, Din Moshe, Weronika Jasinska, Leah Rosental, Eitan Millet, Hanan Sela, Or Sperling, Amir Sharon, Anna Mintz Dub, Yariv Brotman, Nir Sade   +22 more
wiley   +1 more source

Oxidative Stress and NRF2-Mediated Redox Regulation in Incomplete Systemic Lupus Erythematosus and Systemic Lupus Erythematosus. [PDF]

Antioxidants (Basel)
Liu L, Henning S, Goor HV, Bootsma H, Doornbos-van der Meer B, Westra J, Leeuw K.   +6 more
europepmc   +1 more source

Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study. [PDF]

Mult Scler
Yaldizli Ö, Benkert P, Achtnichts L, Bar-Or A, Bohner-Lang V, Bridel C, Comabella M, Findling O, Disanto G, Finkener S, Gobbi C, Granziera C, Herwerth M, Hoepner R, Horakova D, Kamber N, Khalil M, Kunz P, Lalive P, Linker R, Lorscheider J, Müller S, Oechtering J, Pettypool V, Piehl F, Pot C, Roth P, Théaudin M, Tintore M, Tur C, Uffer D, Uginet M, Vehoff J, Wiendl H, Ziemssen T, Zecca C, Salmen A, Leppert D, Derfuss T, Derfuss T, Kappos L, Hemkens LG, Janiaud P, Kuhle J.   +43 more
europepmc   +1 more source

Rhizobial Symbiosis Enhances Salinity Tolerance in Legumes Through Coordinated Physiological and Molecular Responses: Evidence From Common Vetch and Pea

Plant, Cell &Environment, EarlyView.
ABSTRACT Soil salinisation severely constrains crop production. Legumes rely on rhizobial symbiosis for sustainable nitrogen acquisition. Although salinity is known to impair nodulation and nitrogen fixation, how symbiosis influences plant tolerance to salt stress remains unclear.
María Isabel López‐Román, Lucía Zurita, Cristina Castaño‐Herrero, Lucía De la Rosa, Elena Ramírez‐Parra   +4 more
wiley   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

Infusion-related reactions and premedication patterns in ublituximab-treated multiple sclerosis patients: a multicenter real-world study. [PDF]

Front Neurol
Nourelden AZ, Scott PR, Hooshmand SI, Mazur I, Mada F, Ash T, Patel N, Rube J, Yarraguntla K, Deluca C, Yager-Stone P, Havens R, Wallin M, Memon AB.   +13 more
europepmc   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source