Results 181 to 190 of about 2,909 (219)

Matching-adjusted indirect comparisons of diroximel fumarate, ocrelizumab and interferon beta-1a for relapsing multiple sclerosis. [PDF]

J Comp Eff Res
Hersh CM, Aladro-Benito Y, Lewin JB, Shen C, Božin I, Sun Z.   +5 more
europepmc   +1 more source

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source

Patient and healthcare provider experience of diroximel fumarate: considerations for selecting disease-modifying therapy. [PDF]

Neurodegener Dis Manag
Roman C, Garabedian M, Schobel VR, Schneider B, Luce E, Mendoza JP, Lewin JB, Shankar SL.   +7 more
europepmc   +1 more source

Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in Adipocytes

Aging Cell, Volume 25, Issue 4, April 2026.
Phosphoenolpyruvate carboxykinase 1 (Pck1) expression is downregulated in aging white adipose tissue. Adipocyte Pck1 deficiency impairs TCA cycle cataplerosis, causing fumarate accumulation. Excess fumarate disrupts mitochondrial homeostasis, triggers oxidative stress and mtDNA release, activating cGAS–STING signaling and driving inflammaging ...
Yiting Lei, Meng Yang, Xiaoyun Jiang, Yujie Zhang, Yuzhi Chen, Weiheng Xie, Qihui Dai, Weihong Qin, Xiuqin Deng, Xiaojun Zhang, Zhongjun Zhou, Gonghua Huang, Xinguang Liu   +12 more
wiley   +1 more source

Comparative Effectiveness of Disease-Modifying Treatments in Double Seronegative Neuromyelitis Optica Spectrum Disorder. [PDF]

Neurol Neuroimmunol Neuroinflamm
Mahler JV, Vallejos GB, Mikami T, Bilodeau PA, Anderson M, Drosu N, Bobrowski-Khoury N, Silva GD, Solti M, Apóstolos-Pereira SL, Callegaro D, Leles Vieira de Souza B, Manzano GS, Vishnevetsky A, Gillani R, Pasquale O, Kim A, Vij R, Kister I, Gibbons EL, Jacob A, Huda S, Said Y, Krett JD, Sotirchos ES, Ramprasad M, Abboud H, Crelier VTC, Dos Santos G, Uawithya E, Siritho S, Sezen A, Altintas A, Gai F, Guo Y, Bhattacharyya S, Levy M, Matiello M.   +37 more
europepmc   +1 more source

Protective Role for Itaconate During Inhaled Allergen Challenge

Allergy, Volume 81, Issue 4, Page 1099-1110, April 2026.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers, Patricia P. Ogger, Christina Michalaki, Helen Stölting, Simone A. Walker, Anna Caldwell, John M. Halket, Kathryn Duvall, Atia Batool, Lisha Joshi, Helen O'Brien, Cormac McCarthy, Timothy Hinks, Gail M. Gauvreau, Paul M. O'Byrne, Clare M. Lloyd, Adam J. Byrne   +16 more
wiley   +1 more source

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respond in skeletal muscle to support this remarkable resilience.
Audrey Bergouignan, John Noone, Charlotte Brun, Laura Cussonneau, Alexandre Geffroy, Cecile Coudy‐Gandilhon, Isabelle Chery, Alina Lynn Evans, Jon Martin Arnemo, Jonas Kindberg, Guillemette Gauquelin‐Koch, Donal O'Gorman, Etienne Lefai, Fabrice Bertile   +13 more
wiley   +1 more source

Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(sp³)-S stereocentres. [PDF]

Nat Commun
Zhao F, Mattana A, Alam R, Montgomery SL, Pandya A, Manetti F, Dominguez B, Castagnolo D.   +7 more
europepmc   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 8, Page 1089-1098, April 2026.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source

Multiple sclerosis treatment review for primary care providers. [PDF]

Nurse Pract
Hernandez J.
europepmc   +1 more source