Results 21 to 30 of about 2,909 (219)
Stimulation of bone growth with thrombin peptide derivatives [PDF]
, 2005 Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to ...
Carney, Darrell H. +4 more
core +2 more sources
Molecules, 2010 The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a base in the presence of tetrabutylammonium ...
Mohammadreza Zamanloo +3 more
doaj +1 more source
Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery
Pharmaceutics, 2022 Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee +6 more
doaj +1 more source
Drug-induced Fanconi syndrome associated with fumaric acid esters treatment for psoriasis: A case series [PDF]
, 2016 Background: Fumaric acid esters (FAEs), an oral immunomodulating treatment for psoriasis and multiple sclerosis, have been anecdotally associated with proximal renal tubular dysfunction due to a drug-induced Fanconi syndrome.
Balak, D.M.W. (Deepak) +6 more
core +2 more sources
Treatment recommendations for psoriatic arthritis [PDF]
, 2008 Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Ritchlin, CT +15 more
core +1 more source
Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates
Pharmaceutics, 2020 Tenofovir alafenamide fumarate (TAF) is the newest prodrug of tenofovir that constitutes several drug products used for the treatment of HIV/AIDS. Although the solid-state properties of its predecessor tenofovir disoproxil fumarate have been investigated
Hannes Lengauer +7 more
doaj +1 more source
Macromolecular Materials and Engineering, 2023 Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years.
Pradeep Ilayaperumal +4 more
doaj +1 more source
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]
, 2013 3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K. +3 more
core +1 more source
Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse. [PDF]
PLoS ONE, 2010 BACKGROUND: Fumaric acid esters (FAE) are a group of compounds which are currently under investigation as an oral treatment for relapsing-remitting multiple sclerosis.
Darius Moharregh-Khiabani +6 more
doaj +1 more source
Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing-remitting multiple sclerosis [PDF]
, 2014 The last two decades have seen the introduction of several therapies for multiple sclerosis (MS). These therapies are intended to work at different levels of the disease, typically targeting direct symptom management, brief corticosteroid administration ...
GASPERINI, claudio +2 more
core +2 more sources