Results 31 to 40 of about 2,909 (219)

In vitro pharmacokinetics of anti-psoriatic fumaric acid esters [PDF]

, 2004
Background: Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use.
Dissel, J.T. (Jaap) van, Gulpen, C. (Co) van, Litjens, N.H.R. (Nicolle), Mattie, H. (Herman), Nibbering, P.H. (Peter), Strijen, E. (Elizabeth) van, Thio, H.B. (Bing)   +6 more
core   +1 more source

The [4+2]‐Cycloaddition of α‐Nitrosoalkenes with Thiochalcones as a Prototype of Periselective Hetero‐Diels–Alder Reactions—Experimental and Computational Studies [PDF]

, 2020
The [4+2]‐cycloadditions of α‐nitrosoalkenes with thiochalcones occur with high selectivity at the thioketone moiety of the dienophile providing styryl‐substituted 4H‐1,5,2‐oxathiazines in moderate to good yields.
Boger D. L., Carruthers W., Corey E. J., Fleming I., Huisgen R., Huisgen R., Reissig H.-U., Warren S., Zweifel G. S.   +8 more
core   +1 more source

COVID-19 Vaccine Response in People with Multiple Sclerosis Treated with Dimethyl Fumarate, Diroximel Fumarate, Natalizumab, Ocrelizumab, or Interferon Beta Therapy

Neurology and Therapy, 2023
Background Some multiple sclerosis (MS) disease-modifying therapies (DMTs) impair responses to vaccines, emphasizing the importance of understanding COVID-19 vaccine immune responses in people with MS (PwMS) receiving different DMTs.
Aliya Jaber, Meera Patel, Andrew Sylvester, Mary Yarussi, J. Tamar Kalina, Jason P. Mendoza, Robin L. Avila, Matthew A. Tremblay   +7 more
doaj   +1 more source

Oral fumaric acid esters for psoriasis: abridged Cochrane systematic review including GRADE assessments [PDF]

, 2016
Fumaric acid esters (FAE) are licensed for the treatment of moderate to severe psoriasis in Germany but are also used off-label in many other countries.
Abbott, Rachel, Atwan, A., Bauer, A., Ingram, John R., Kelson, Mark James, Pickles, Timothy E., Piguet, Vincent   +6 more
core   +1 more source

Outbreak of eczema and rhinitis in a group of office workers in Greenland [PDF]

International Journal of Circumpolar Health, 2015
Introduction: Disturbed indoor climate may in some cases be associated with illness. In the present paper, we report the results from a thorough investigation of office workers in Greenland, who developed skin and/or airway problems after moving into ...
Niels E. Ebbehøj, Tove Agner, Erik Zimerson, Magnus Bruze   +3 more
doaj   +1 more source

In vivo cortical glutathione response to oral fumarate therapy in relapsing-remitting multiple sclerosis: A single-arm open-label phase IV trial using 7-Tesla 1H MRS

NeuroImage: Clinical, 2023
Background: This is an open-label, single-arm, single-center pilot study using 7-Tesla in vivo proton magnetic resonance spectroscopy (1H MRS) to measure brain cortical glutathione concentration at baseline before and during the use of oral fumarates as ...
Christoph Juchem, Kelley M. Swanberg, Hetty Prinsen, Daniel Pelletier   +3 more
doaj   +1 more source

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties [PDF]

, 2015
INTRODUCTION: Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis.
Gregory R. J. Thatcher, Irida Kastrati, Jonna Frasor, Manuel Alvarez, Shuangping Zhao, Vladislav A. Litosh   +5 more
core   +1 more source

Novel drug development for neuromuscular blockade

Journal of Anaesthesiology Clinical Pharmacology, 2016
Pharmacological advances in anesthesia in recent decades have resulted in safer practice and better outcomes. These advances include improvement in anesthesia drugs with regard to efficacy and safety profiles.
Amit Prabhakar, Alan D Kaye, Melville Q Wyche, Orlando J Salinas, Kenneth Mancuso, Richard D Urman   +5 more
doaj   +1 more source

Breaking the cycle: reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate [PDF]

, 2019
Objective To infer molecular effectors of therapeutic effects and adverse events for dimethyl fumarate (DMF) in relapsing-remitting MS patients (RRMS) using untargeted plasma metabolomics.
David, M. J., Gafson, A. R., Gomez-Romero, M., Heslegrave, A., Lewis, M. R., Matthews, P. M., Nicholas, R., Nicholson, J., Savva, C., Thorne, Tom, Zetterberg, H.   +10 more
core   +3 more sources

Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate [PDF]

, 2015
BACKGROUND: Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence.
Antje Bornemann, Felix Bischof, Nele Dammeier, Till-Karsten Hauser, Victoria Schubert   +4 more
core   +1 more source