Results 21 to 30 of about 2,275 (253)
Bioavailable central nervous system disease-modifying therapies for multiple sclerosis
Frontiers in Immunology, 2023 Disease-modifying therapies for relapsing multiple sclerosis reduce relapse rates by suppressing peripheral immune cells but have limited efficacy in progressive forms of the disease where cells in the central nervous system play a critical role.
Hans-Peter Hartung +8 more
doaj +1 more source
Hospital Pharmacy, 2013 Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
Cada, Dennis J +2 more
openaire +3 more sources
Pharmaceuticals, 2022 Dimethyl fumarate (DMF) has emerged as a first-line therapy for relapsing-remitting multiple sclerosis (RRMS). This treatment, however, has been limited by adverse effects, which has prompted development of novel derivatives with improved tolerability ...
William R. Swindell +2 more
doaj +1 more source
Unusual Formation of 1,2,4-Oxadiazine Core in Reaction of Amidoximes with Maleic or Fumaric Esters
Molecules, 2022 We have developed a simple and convenient method for the synthesis of 3-aryl- and 3-hetaryl-1,2,4-oxadiazin-5-ones bearing an easily functionalizable (methoxycarbonyl)methyl group at position 6 via the reaction of aryl or hetaryl amidoximes with maleates
Sofia I. Presnukhina +6 more
doaj +1 more source
Conjugate Addition/Ireland−Claisen Rearrangements of Allyl Fumarates: Simple Access to Terminally Differentiated Succinates [PDF]
, 2008 The conjugate addition of dialkylzinc reagents to allyl fumarates with subsequent Ireland–Claisen rearrangement has been accomplished yielding substituted unsymmetrical succinic acid derivatives.
Bausch, Cory C., Johnson, Jeffrey S.
core +1 more source
, 2016 The conjugate addition of dialkylzinc reagents to allyl fumarates with subsequent Ireland−Claisen rearrangement has been accomplished yielding substituted unsymmetrical succinic acid derivatives.
Jeffrey S. Johnson (1312380) +1 more
core +3 more sources
Molecules, 2010 The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a base in the presence of tetrabutylammonium ...
Mohammadreza Zamanloo +3 more
doaj +1 more source
Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery
Pharmaceutics, 2022 Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee +6 more
doaj +1 more source