Results 51 to 60 of about 3,137 (203)
Family-specific scaling laws in bacterial genomes [PDF]
, 2017 Among several quantitative invariants found in evolutionary genomics, one of the most striking is the scaling of the overall abundance of proteins, or protein domains, sharing a specific functional annotation across genomes of given size.
de Lazzari, Eleonora +3 more
core +3 more sources
Effect of ligands to toll-like receptors (TLR) 3, 7 and 9 on mice infected with mouse hepatitis virus A59 [PDF]
, 2014 Mice infected with mouse hepatitis virus A59 (MHV-A59), an enveloped, positive-strand RNA Co-ronavirus, induce hepatitis, thymus involution, IgG2a-restricted hypergammaglobulinaemia, transaminase release and autoantibodies (autoAb) to liver and kidney ...
Aparicio, Jose Luis +2 more
core +1 more source
Disruption of Fumarylacetoacetate Hydrolase Causes Spontaneous Cell Death under Short-Day Conditions in Arabidopsis [PDF]
Plant Physiology, 2013 Fumarylacetoacetate hydrolase (FAH) hydrolyzes fumarylacetoacetate to fumarate and acetoacetate, the final step in the tyrosine (Tyr) degradation pathway that is essential to animals. Deficiency of FAH in animals results in an inborn lethal disorder. However, the role for the Tyr degradation pathway in plants remains to be elucidated. In this study, we
Chengyun Han +7 more
openaire +2 more sources
Girl With Tyrosinemia Type 1 and Executive Dysfunctions Treated With Methylphenidate
Journal of Inborn Errors of Metabolism and Screening, 2018 Hereditary tyrosinemia type 1 (HT1; OMIM 27670) is an inborn error of tyrosine metabolism, caused by a deficiency of the enzyme fumarylacetoacetate hydrolase.
Annik Simons MD +4 more
doaj +1 more source
Ibrain, 2023 Due to the existence of the blood–brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instructive to ...
Ji‐Yan Wang +6 more
doaj +1 more source
Hepatitis C virus infection and related liver disease: the quest for the best animal model [PDF]
, 2013 Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma (HCC) making the virus the most common cause of liver failure and transplantation.
Baumert, Thomas F +4 more
core +3 more sources
First Macedonian child with tyrosinemia type 1 successfully treated with nitisinone and report of a novel mutation in the FAH gene [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2017 Introduction. Hereditary tyrosinemia type 1 (HT1) is a severe hereditary metabolic disorder of tyrosine metabolism due to fumarylacetoacetate hydrolase (FAH) deficiency and accumulation of toxic products in tissues. More than 80 mutations in the FAH gene
Kostovski Aco +3 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2021 Hereditary tyrosinemia type I (HT1) results from the loss of fumarylacetoacetate hydrolase (FAH) activity and can lead to lethal liver injury (LLI). Therapeutic options for HT1 remain limited.
Peng Gu +12 more
doaj +1 more source
Contribution of human hematopoietic stem cells to liver repair [PDF]
, 2009 Immune-deficient mouse models of liver damage allow examination of human stem cell migration to sites of damage and subsequent contribution to repair and survival.
Ping Zhou +97 more
core +2 more sources
Molecular Therapy: Methods & Clinical Development, 2020 The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large ...
Clara T. Nicolas +23 more
doaj +1 more source