Results 101 to 110 of about 5,939,728 (334)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Measure Fields for Function Approximation
, 1993 The computation of a piecewise smooth function that approximates a finite set of data points may be decomposed into two decoupled tasks: first, the computation of the locally smooth models, and hence, the segmentation of the data into classes that ...
Marroquin, Jose L.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Function approximation using combined unsupervised and supervised learning
, 2014 Function approximation is one of the core tasks that are solved using neural networks in the context of many engineering problems. However, good approximation results need good sampling of the data space, which usually requires exponentially increasing ...
Andras, Peter
core +1 more source
SensorsIn this paper, the optimal approximation algorithm is proposed to simplify non-linear functions and/or discrete data as piecewise polynomials by using the constrained least squares.
Jieun Song, Bumjoo Lee
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Approximation by Rational Functions [PDF]
Proceedings of the American Mathematical Society, 1986 Making use of the Hardy-Littlewood maximal function, we give a new proof of the following theorem of Pekarski: If f ′ f’
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Approximation for the gamma function via the tri-gamma function
Journal of Inequalities and Applications, 2017 In this paper, we present a new sharp approximation for the gamma function via the tri-gamma function. This approximation is fast in comparison with the recently discovered asymptotic series.
Xu You, Xiaocui Li
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Approximately Subharmonic Functions [PDF]
Proceedings of the American Mathematical Society, 1952 for 0
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