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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source

Continuous State Dynamic Programming via Nonexpansive Approximation [PDF]

This paper studies fitted value iteration for continuous state dynamic programming using nonexpansive function approximators. A number of nonexpansive approximation schemes are discussed.
John Stachurski
core +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source

General Approach to Function Approximation

Mathematics
Applying a predefined set of functionals to a function provides a set of numbers which characterize the function. One can then interpret an approximation very generally as a construction of some function form which reproduces these numbers if the same ...
Andrej Liptaj
doaj +1 more source

Analytic Function Approximation by Path-Norm-Regularized Deep Neural Networks. [PDF]

Entropy (Basel), 2022
Beknazaryan A.
europepmc +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source

Deep Learning and Its Application to Function Approximation for MR in Medicine: An Overview. [PDF]

Magn Reson Med Sci, 2022
Takeshima H.
europepmc +1 more source

Approximation Error Bounds via Rademacher's Complexity

, 2008
Approximation properties of some connectionistic models, commonly used to construct approximation schemes for optimization problems with multivariable functions as admissible solutions, are investigated.
Gnecco, Giorgio, Sanguineti, Marcello
core

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source

Coherency-Constrained Spectral Clustering for Power Network Reduction

IEEE Open Access Journal of Power and Energy
This paper presents a methodology for reducing the complexity of large-scale power network models using spectral clustering, aggregation of electrical components, and cost function approximation.
Mario D. Baquedano-Aguilar, Sean Meyn, Arturo Bretas +2 more
doaj +1 more source

fourier series
reinforcement learning
neural networks

deep learning
activation function
machine learning