Results 91 to 100 of about 14,894,566 (393)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs [PDF]

, 2022
Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty   +3 more
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Influence of implant macrodesign and insertion load during implant placement on primary stability in artificial bone

International Journal of Implant Dentistry
Background Implant placement is a critical step for achieving primary stability. During this process, a compressive force, referred to as an “insertion load,” is applied through a handpiece or manual driver.
Yiwen Wang, Yoko Yamaguchi, Poyuan Hsueh, Daisuke Higuchi   +3 more
doaj   +1 more source

Chromatin remodeling complexes: architects influencing breast cancer progression

Frontiers in Cell and Developmental Biology
As one of the most common types of cancer, breast cancer strongly contributes to the increase in morbidity and mortality worldwide. Alterations in the genetic and epigenetic landscape contribute to the complexity and heterogeneity of the disease, making ...
Octavianus Giovani, Grace S. Eckersley, Hayden R. Jones, Sankari Nagarajan   +3 more
doaj   +1 more source

Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

eLife, 2020
Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational landscape (‘mutator phenotype’) of some cancers, however, the basis of this sporadic vulnerability is unknown.
Birong Shen, Joseph H Chapman, Michael F Custance, Gianna M Tricola, Charles E Jones, Anthony V Furano   +5 more
doaj   +1 more source

Boolean nested canalizing functions: a comprehensive analysis

, 2013
Boolean network models of molecular regulatory networks have been used successfully in computational systems biology. The Boolean functions that appear in published models tend to have special properties, in particular the property of being nested ...
Adeyeye, John O., Aguilar, Boris, Laubenbacher, Reinhard, Li, Yuan, Murrugarra, David   +4 more
core   +1 more source

Chiral separation in microflows [PDF]

, 2005
Molecules that only differ by their chirality, so called enantiomers, often possess different properties with respect to their biological function. Therefore, the separation of enantiomers presents a prominent challenge in molecular biology and belongs ...
A. J. Lichtenberg, D. Figeys, J. K. G. Dhont, Marcin Kostur, Michael Schindler, Peter Hänggi, Peter Talkner, R. D. Astumian, S. Ahuja   +8 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source