Results 51 to 60 of about 14,637,911 (412)
The structural basis of translational control by eIF2 phosphorylation
Nature Communications, 2019 During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B.
Tomas Adomavicius +6 more
doaj +1 more source
Reduced efficacy of a Src kinase inhibitor in crowded protein solution
Nature Communications, 2021 The intracellular compartment is a crowded environment. Here, the authors use molecular dynamics (MD) simulations to assess inhibitor binding to c-Src kinase and show how ligand binding pathways differ in crowded and dilute protein solutions ...
Kento Kasahara +10 more
doaj +1 more source
Nature Communications, 2018 The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells ...
Stephen J. Pettitt +22 more
doaj +1 more source
Ten Simple Rules for Creating Biomolecular Graphics [PDF]
PLoS Computational Biology (2010), 6(8): e1000918, 2014 One need only compare the number of three-dimensional molecular illustrations in the first (1990) and third (2004) editions of Voet & Voet's "Biochemistry" in order to appreciate this field's profound communicative value in modern biological sciences -- ranging from medicine, physiology, and cell biology, to pharmaceutical chemistry and drug design, to
arxiv +1 more source
BIOLOGY AND FUNCTIONS OF NERVE CELLS [PDF]
The Journal OF Nervous and Mental Disease, 1922 n ...
openaire +2 more sources
Population Ecology, EarlyView.In the process of captive breeding and reintroduction of endangered animal species, it is crucial to minimize familial bias in reproductive success during the reintroduction phase to preserve genetic diversity. In this study, we attempted to identify the familial lineage of individuals of the endangered bagrid fish Tachysurus ichikawai born at the ...
Hinano Mizuno +5 more
wiley +1 more source
Primate Craniofacial Function and Biology [PDF]
, 2010 Book review: Primate Craniofacial Function and ...
Constantino, Paul J
core +4 more sources
Specificity, propagation, and memory of pericentric heterochromatin
Molecular Systems Biology, 2014 The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric ...
Katharina Müller‐Ott +11 more
doaj +1 more source
'Causa efficiens' versus 'Causa finalis': functional explanations in biology [PDF]
, 2011 Biology differs from most sciences in its particular way of dealing with the term ‘function’. On the one hand, questions like ‘What is the function of a trait x?’ seem to be perfectly legitimate, realizing that (most) biologists acknowledge that ...
Kosolosky, Laszlo
core +1 more source
The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models [PDF]
, 2012 LetterThis is the final version of the article. Available from SAGE Publications via the DOI in this record.Time-dependent light input is an important feature of computational models of the circadian clock.
Adams, RR +8 more
core +1 more source