Results 41 to 50 of about 488,957 (273)

Modeling and Optimizing the System Reliability Using Bounded Geometric Programming Approach

open access: yesMathematics, 2022
The geometric programming problem (GPP) is a beneficial mathematical programming problem for modeling and optimizing nonlinear optimization problems in various engineering fields.
Shafiq Ahmad   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Transformation operators for impedance Sturm–Liouville operators on the line

open access: yesМатематичні Студії, 2023
In the Hilbert space $H:=L_2(\mathbb{R})$, we consider the impedance Sturm--Liouville operator $T:H\to H$ generated by the differential expression $ -p\frac{d}{dx}{\frac1{p^2}}\frac{d}{dx}p$, where the function  $p:\mathbb{R}\to\mathbb{R}_+$ is of ...
M. Kazanivskiy   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Bounded variation solutions to Sturm-Liouville problems

open access: yesElectronic Journal of Differential Equations, 2018
In this article we consider singular Sturm-Liouville problems whose right-hand side is a function of bounded Jordan variation. We present necessary and sufficient conditions for all solutions to be of bounded Jordan variation.
Jacek Gulgowski
doaj  

Spectral Synthesis of Functions of Bounded Variation [PDF]

open access: yesProceedings of the American Mathematical Society, 1975
It is proved that every bounded measurable function on ( − ∞ , ∞ ) ( - \infty ,\infty ) which for some constant a > 0 a > 0 is of bounded variation on ( − ∞ , − a ) ( - \infty , - a)
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Rate of convergence of beta operators of second kind for functions with derivatives of bounded variation

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2005
We study the approximation properties of beta operators of second kind. We obtain the rate of convergence of these operators for absolutely continuous functions having a derivative equivalent to a function of bounded variation.
Vijay Gupta, Ulrich Abel, Mircea Ivan
doaj   +1 more source

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