Results 121 to 130 of about 2,857,572 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nonlinear Inequality, Fixed Point and NashEquilibrium [PDF]
In this paper, we give new sufficient conditions for the existence of a solution of theg-maximum equality. As a consequence, we prove a new fixed point theorem.
Moussa Larbani +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2010 peer reviewedElectron tomography is a unique technique for imaging the microstructure of materials with a nanometer resolution. The signal to noise ratio of electron tomograms is, however, often too low for a reliable segmentation-based image analysis ...
de Jongh, P.E. +13 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
PtProcess: An R Package for Modelling Marked Point Processes Indexed by Time
This paper describes the package PtProcess which uses the R statistical language. The package provides a unified approach to fitting and simulating a wide variety of temporal point process or temporal marked point process models. The models are specified
David Harte
core
Distance-Based Methods: Ripley’s K function vs. K density function [PDF]
In this paper, we propose an analytical and methodological comparison between two of the most known distance-based methods in the evaluation of the geographic concentration of economic activity.
Marta R. Casanova +3 more
core
Multivalued generalizations of fixed point results in fuzzy metric spaces
, 2016 This paper attempts to prove fixed and coincidence point results in fuzzy metric space using multivalued mappings. Altering distance function and multivalued strong {bn}-fuzzy contraction are used in order to do that.
Radenovic, Stojan +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source