Results 111 to 120 of about 6,309,373 (323)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

The meaning and change in the function of communal space in Lamin house

open access: yesARTEKS : Jurnal Teknik Arsitektur
In the modern era, many traditional houses have changed to functional spaces, as stated in several journals, including the Lamin house in East Kalimantan.
Abdul Mufti Radja   +3 more
doaj   +1 more source

Quasiminimal distal function space and its semigroup compactification

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1995
Quasiminimal distal function on a semitopological semigroup is introduced. The concept of right topological semigroup compactification is employed to study the algebra of quasiminimal distal functions.
R. D. Pandian
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Function of space in Daniel 1

open access: yesIn die Skriflig, 2014
Daniel 1 narrates how Daniel and his friends come from Jerusalem and are appointed as officials at the royal court in Babylon. The narrative is governed by the various and significant references to space.
Marius Nel
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The Approximation Characteristics of Weighted Band-Limited Function Space

open access: yesMathematics
This article primarily investigates the width problem within weighted band-limited function space in a uniform setting. Through an analysis of the properties of s-numbers, we establish a connection between the widths of weighted band-limited function ...
Yue Li   +3 more
doaj   +1 more source

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