Results 111 to 120 of about 830,258 (268)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A disproportionality analysis of real-world adverse events associated with tirofiban from the FAERS database

Scientific Reports
Tirofiban is a glycoprotein IIb/IIIa receptor blocker mainly used alongside other blood thinners in patients with acute coronary syndrome (ACS) undergoing procedures like angioplasty (PCI).
Qian Guo, Xiang Li, Chuanliang Zhao, Yaxing Li, Yang Mao, Chungang Zhai, Lei Zhang, Xingli Xu, Wenjie Tian   +8 more
doaj   +1 more source

USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377

Research
Alcoholic cardiomyopathy (ACM) is a type of dilated cardiomyopathy unrelated to ischemia, which develops as a consequence of chronic alcohol consumption.
Jichen Pan, Xiaolin Liu, Xiao Li, Shanshan Wang, Yuliang Zhao, Chong Yuan, Dongdong Liu, Liyan Wang, Meng Zhang, Fengming Liu, Mei Zhang, Shen Dai   +11 more
doaj   +1 more source

Osgood’s theory of functions [PDF]

Bulletin of the American Mathematical Society, 1907
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

(Yeni) Bir Sözlükbilim Teorisine İhtiyacımız Var mı? Sven Tarp

Dil ve Edebiyat Araştırmaları Dergisi, 2014
Hâlihazırdaki basılı sözlüklerden elektronik sözlüklere geçiş evresinde, sözlükbilimsel elektronik araçların anlayış ve üretimine rehberlik edebilecek yeni bir sözlükbilim teorisine ihtiyaç duyup duymadığımız ya da zaten basılmış eserler döneminde ...
Çeviren: Fatih Doğru
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Perbedaan Model dan Teori dalam Ilmu Komunikasi

Humaniora, 2014
This article aims to describe differences in models and theories of communication and their respective roles. Many students of Communication Studies do not really care because it was considered too elementary. Students tend to focus on the "big things",
Bambang A. S.
doaj  

PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications

The Journal of Clinical Hypertension
Hypertension is a multifactorial condition influenced by both genetic and environmental factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to increased blood pressure.
Hongtao Lan, Yingbin Xi, Baoxu Kang, Zhoujie Tong, Jie Peng, Wei Zhang, Ming Zhong, Huiping Gong, Zhihao Wang   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source