Results 91 to 100 of about 6,187,037 (287)
Frontiers in MedicineBackgroundSevere aortic stenosis (AS) imposes sustained pressure overload on the left ventricle, leading to hypertrophy and myocardial fibrosis, which are key features of adverse cardiac remodeling.
Xiaoqian Sun +10 more
doaj +1 more source
Instanton Counting and Chern-Simons Theory
, 2003 The instanton partition function of N=2, D=4 SU(2) gauge theory is obtained by taking the field theory limit of the topological open string partition function, given by a Chern-Simons theory, of a CY3-fold.
Iqbal, Amer, Kashani-Poor, Amir-Kian
core +3 more sources
Function attribution depends on the explanatory context: A Reply to Neander and Rosenberg's Reply to Nanay [PDF]
, 2012 In ‘A modal theory of function’, I gave an argument against all existing theories of function and outlined a new theory. Karen Neander and Alex Rosenberg argue against both my negative and my positive claim.
Nanay, Bence
core
From Density Functional Theory to Conceptual Density Functional Theory and Biosystems
Pharmaceuticals, 2022 The position of conceptual density functional theory (CDFT) in the history of density functional theory (DFT) is sketched followed by a chronological report on the introduction of the various DFT descriptors such as the electronegativity, hardness, softness, Fukui function, local version of softness and hardness, dual descriptor, linear response ...
openaire +4 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Pharmacological ResearchInterleukin-17 (IL-17), a pleiotropic cytokine produced by Th17 cells and innate immune cells, plays a pivotal role in cardiovascular diseases (CVDs) by bridging innate and adaptive immunity.
Lianyue Ma +6 more
doaj +1 more source
Tame Class Field Theory for Global Function Fields
, 2015 We give a function field specific, algebraic proof of the main results of class field theory for abelian extensions of degree coprime to the characteristic.
Florian Hess +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source