Results 71 to 80 of about 6,187,037 (287)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

A retrospective analysis of systolic blood pressure time in target range among patients in coronary care unit

open access: yesScientific Reports
The research aimed to illustrate the prognostic value of systolic blood pressure time in target range (SBP-TTR) calculated by continuously monitoring blood pressure (BP) records among patients admitted to coronary care units.
Qiufeng Jia   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The Incorporation of Specialised Data in Lexicographical Meaning Explanations: A Discussion Based on Sports and Fitness Terms

open access: yesLexikos, 2016
There is a problematic treatment of field specific words in both general language dictionaries as well as specialised dictionaries, which in this paper is exemplified using the sports and fitness subject fields as the point of departure and focusing on ...
Heidi Agerbo
doaj   +1 more source

The $\beta$-function for Yukawa theory at large $N_f$

open access: yes, 2018
We compute the $\beta$-function for a massless Yukawa theory in a closed form at the order $\mathcal{O}(1/N_f)$ in the spirit of the expansion in a large number of flavours $N_f$.
Alanne, Tommi, Blasi, Simone
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

On the disciplinary and functional status of economic lexicography [PDF]

open access: yesIbérica, 2015
Dictionaries of Economics in the broad sense of the word have existed in the European context for more than 300 years. The article shows how these dictionaries have been extremely flexible in their adaptation to the complex and ever changing needs of ...
Sven Tarp
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Old Wisdom: The Highly Relevant Lexicographical Knowledge Obtainable from a Specialized Dictionary from 1774

open access: yesLexikos, 2013
There is little doubt that lexicography has experienced important progress during the years, especially when one compare the lexicographical works from the various centuries.
Sven Tarp
doaj   +1 more source

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