Results 71 to 80 of about 832,157 (268)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Battle for Inbox and Bucks

Journal of Quantitative Description: Digital Media
Despite its proven pervasiveness and effectiveness, the role of email in political campaigns has been understudied. In this article, we seek to understand the use of emails by Donald Trump's and Joe Biden's campaigns during the 2020 U.S.
Bin Chen, Porismita Borah, Ross Dahlke, Josephine Lukito   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

g-FUNCTION IN PERTURBATION THEORY [PDF]

International Journal of Modern Physics A, 2004
We present some explicit computations checking a particular form of gradient formula for a boundary beta function in two-dimensional quantum field theory on a disk. The form of the potential function and metric that we consider were introduced in Refs. 16 and 18 in the context of background independent open string field theory.
openaire   +2 more sources

ZFP36 Protects against Abdominal Aortic Aneurysm Formation by Regulating Vascular Smooth Muscle Phenotypic Switch

Research
Abdominal aortic aneurysm (AAA) is a life-threatening aortic disease without effective pharmacological therapies. Mounting evidences suggested that RNA-binding proteins (RBPs) exert pivotal roles in various diseases including AAA.
Zhinan Wu, Hanlin Lu, Tingting Liu, Xiaolin Yue, Lei Wang, Chang Ma, Pavel Kovarik, Xiangjiu Ding, Mo Wang, Cheng Zhang, Jianmin Yang, Wencheng Zhang   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Balloon dilation in sheath technique in transcatheter aortic valve replacement via narrow femoral artery: first-in-human early feasibility study

Frontiers in Medicine
BackgroundSevere aortic stenosis (AS) imposes sustained pressure overload on the left ventricle, leading to hypertrophy and myocardial fibrosis, which are key features of adverse cardiac remodeling.
Xiaoqian Sun, Xiangjuan Liu, Luyao An, Liangyi Qie, Lianyue Ma, Xiao Meng, Huixia Lu, Guihua Yao, Guihua Yao, Mei Dong, Guipeng An   +10 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Enhanced prediction of coronary heart disease risk in diabetic patients via Machine learning incorporating multiple inflammatory and metabolic indices: A study with Dual-Cohort validation

International Journal of Cardiology: Heart & Vasculature
Background: Coronary heart disease (CHD) remains a leading cause of mortality worldwide, with individuals with diabetes mellitus (DM) facing markedly elevated risk due to complex inflammatory and metabolic disturbances.
Pinpeng Xie, Xiangzhen Ran, Weichun Zhu, Yunfang Xie, Youran Dong, Zhiyuan Wang, Chungang Zhai, Lei Qiao, Jianmin Yang, Wenqiang Chen   +9 more
doaj   +1 more source