Results 71 to 80 of about 830,258 (268)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Battle for Inbox and Bucks

Journal of Quantitative Description: Digital Media
Despite its proven pervasiveness and effectiveness, the role of email in political campaigns has been understudied. In this article, we seek to understand the use of emails by Donald Trump's and Joe Biden's campaigns during the 2020 U.S.
Bin Chen, Porismita Borah, Ross Dahlke, Josephine Lukito   +3 more
doaj   +1 more source

A Unifying Theory of Biological Function [PDF]

Biological Theory, 2017
A new theory that naturalizes biological function is explained and compared with earlier etiological and causal role theories. Etiological (or selected effects) theories explain functions from how they are caused over their evolutionary history. Causal role theories analyze how functional mechanisms serve the current capacities of their containing ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ZFP36 Protects against Abdominal Aortic Aneurysm Formation by Regulating Vascular Smooth Muscle Phenotypic Switch

Research
Abdominal aortic aneurysm (AAA) is a life-threatening aortic disease without effective pharmacological therapies. Mounting evidences suggested that RNA-binding proteins (RBPs) exert pivotal roles in various diseases including AAA.
Zhinan Wu, Hanlin Lu, Tingting Liu, Xiaolin Yue, Lei Wang, Chang Ma, Pavel Kovarik, Xiangjiu Ding, Mo Wang, Cheng Zhang, Jianmin Yang, Wencheng Zhang   +11 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Balloon dilation in sheath technique in transcatheter aortic valve replacement via narrow femoral artery: first-in-human early feasibility study

Frontiers in Medicine
BackgroundSevere aortic stenosis (AS) imposes sustained pressure overload on the left ventricle, leading to hypertrophy and myocardial fibrosis, which are key features of adverse cardiac remodeling.
Xiaoqian Sun, Xiangjuan Liu, Luyao An, Liangyi Qie, Lianyue Ma, Xiao Meng, Huixia Lu, Guihua Yao, Guihua Yao, Mei Dong, Guipeng An   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Lexicography for the third millennium: Cognitive-oriented specialised dictionaries for learners [PDF]

Ibérica, 2011
Emphasis on the functional approach to lexicography, for example the so-called Function Theory of Lexicography proposed by Bergenholtz and Tarp (2002, 2003 & 2004; see Tarp 2008 for a review), has promoted the vision that lexicography is at a crossroads ...
Pedro A. Fuertes-Olivera, Sven Tarp
doaj