Results 91 to 100 of about 11,568 (285)

Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils [PDF]

, 2010
Amyloid fibrils are important in diverse cellular functions, feature in many human diseases and have potential applications in nanotechnology. Here we describe methods that combine optical trapping and fluorescent imaging to characterize the forces that ...
A Karsai, A Kishimoto, A Santoso, AF Oberhauser, AH DePace, BH Toyama, C Bustamante, C Cecconi, Carlos E Castro, CB Andersen, CC Lee, CM Dobson, DJ Brockwell, DJ Selkoe, DN Greene, DS Kryndushkin, EP Raman, F Shewmaker, GI Bell, H Wang, HE White, IH Cheng, J Shorter, J Zhang, JCM Gebhardt, Jijun Dong, JJ Liu, JJ Liu, JR Glover, JS Palmer, KC Neuman, L Tskhovrebova, M Carrion-Vazquez, M Tanaka, M Tanaka, Mary C Boyce, Matthew J Lang, MJ Lang, MM Pallitto, MSZ Kellermayer, MSZ Kellermayer, MSZ Kellermayer, MT Woodside, N Sondheimer, ND Lazo, OK Dudko, P Bechtluft, P Satpute-Krishnan, PM Douglas, PM Tessier, PM Tessier, R Krishnan, R Nelson, S Keten, SC Yang, SM Block, SM Uptain, SR Collins, Susan Lindquist, SV Paushkin, T Scheibel, TR Serio, Y Cao, Y Cao, YO Chernoff   +64 more
core   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Prion‐like proteins: from computational approaches to proteome‐wide analysis

FEBS Open Bio, 2021
Prions are self‐perpetuating proteins able to switch between a soluble state and an aggregated‐and‐transmissible conformation. These proteinaceous entities have been widely studied in yeast, where they are involved in hereditable phenotypic adaptations ...
Marcos Gil‐Garcia, Valentín Iglesias, Irantzu Pallarès, Salvador Ventura   +3 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Directing curli polymerization with DNA origami nucleators

Nature Communications, 2019
Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and ...
Xiuhai Mao, Ke Li, Mengmeng Liu, Xinyu Wang, Tianxin Zhao, Bolin An, Mengkui Cui, Yingfeng Li, Jiahua Pu, Jiang Li, Lihua Wang, Timothy K. Lu, Chunhai Fan, Chao Zhong   +13 more
doaj   +1 more source

Unified perspective on proteins: A physics approach

, 2004
We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of protein-like properties. The constructive hypothesis that this striking resemblance is not accidental leads
Banavar, Jayanth R., Hoang, Trinh Xuan, Maritan, Amos, Seno, Flavio, Trovato, Antonio   +4 more
core   +1 more source

Inflammasome priming in sterile inflammatory disease [PDF]

, 2017
The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur
Bryant, Clare E., Carroll, Richard G., Galván-Peña, Silvia, Masters, Seth L., Mills, Evanna L., Olden, Robin, Patel, Meghana N., Triantafilou, Kathy, Triantafilou, Martha, Wolf, Amaya I.   +9 more
core   +2 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source