Results 101 to 110 of about 3,255,404 (222)

Evaluation of Aggregated Ag85B Antigen for Its Biophysical Properties, Immunogenicity, and Vaccination Potential in a Murine Model of Tuberculosis Infection

Frontiers in Immunology, 2017
Protein aggregates have been reported to act as a reservoir that can release biologically active, native form of precursor protein. Keeping this fact into consideration, it is tempting to exploit protein aggregate-based antigen delivery system as a ...
Faraz Ahmad, Swaleha Zubair, Pushpa Gupta, Umesh Datta Gupta, Rakesh Patel, Mohammad Owais   +5 more
doaj   +1 more source

Functional Amyloids in Pseudomonas aeruginosa Are Essential for the Proteome Modulation That Leads to Pathoadaptation in Pulmonary Niches. [PDF]

Microbiol Spectr, 2023
Beg AZ, Rashid F, Talat A, Haseen MA, Raza N, Akhtar K, Dueholm MKD, Khan AU.   +7 more
europepmc   +1 more source

Bacterial inclusion bodies are industrially exploitable amyloids

, 2021
Altres ajuts: CERCA Programme/Generalitat de CatalunyaUnderstanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest.
De Marco, Ario, Vázquez Gómez, Esther, García Fruitós, Elena, Mitraki, Anna, Valdez-Cruz, Norma A., Villaverde Corrales, Antonio, Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia, Ferrer Miralles, Neus, Rinas, Ursula, Peternel, Spela, Trujillo-Roldán, Mauricio A.   +10 more
core  

Unexpected Importance of Aromatic-Aliphatic and Aliphatic Side Chain-Backbone Interactions in the Stability of Amyloids [PDF]

, 2017
The role of aromatic and nonaromatic amino acids in amyloid formation has been elucidated by calculating interaction energies between -sheets in amyloid model systems using density functional theory (B3LYP-D3/6-31G*).
Predrag V. Petrović, Ninković, Dragan, Niu, Shuqiang, Belić, Milivoj R., Michael B. Hall, Edward N. Brothers, Snežana D. Zarić, Petrović, Predrag, Brothers, Edward N., Milivoj R. Belić, Malenov, Dušan, Shuqiang Niu, Zarić, Snežana D., Dragan B. Ninković, Hall, Michael B., Dušan P. Malenov   +15 more
core   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Structural insight into Escherichia coli CsgA amyloid fibril assembly

mBio
The discovery of functional amyloids in bacteria dates back several decades, and our understanding of the Escherichia coli curli biogenesis system has gradually expanded over time.
Fan Bu, Derek R. Dee, Bin Liu
doaj   +1 more source

Amyloids-a neglected child of the slime

, 2016
Functional amyloids define a group of highly ordered fibrillar protein polymers, which are characterized by a cross quaternary structure, an ability to self-assemble from their monomeric counterparts, and an extreme resistance towards thermal and ...
Dueholm, Morten S.; id_orcid, Nielsen, Per Halkjaer   +1 more
core  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Enzymes of physiological amyloidogenesis control pathological amyloid toxicity

Life Science Alliance
This study finds that modulating RNA tailing and decay enzymes can regulate proteotoxicity in Alzheimer’s and Parkinson’s disease models. Physiological amyloidogenesis drives the formation of functional amyloids involved in various biochemical pathways ...
Michael Bokros, Alex Grunfeld, Nathan C Balukoff, Jessica Bouviere, Eléonore Beurel, Stephen Lee   +5 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source