Results 61 to 70 of about 557,186 (345)

From chunks to function-argument structure : a similarity-based approach [PDF]

, 2001
Chunk parsing has focused on the recognition of partial constituent structures at the level of individual chunks. Little attention has been paid to the question of how such partial analyses can be combined into larger structures for complete utterances ...
Hinrichs, Erhard, Kübler, Sandra
core   +4 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

PocketAnnotate: towards site-based function annotation [PDF]

Nucleic Acids Research, 2012
A computational pipeline PocketAnnotate for functional annotation of proteins at the level of binding sites has been proposed in this study. The pipeline integrates three in-house algorithms for site-based function annotation: PocketDepth, for prediction of binding sites in protein structures; PocketMatch, for rapid comparison of binding sites and ...
Anand, Praveen, Yeturu, Kalidas, Chandra, Nagasuma   +2 more
openaire   +4 more sources

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Functional Annotation and Analysis of Genetic Variants

IEEE Access, 2023
The process of functional annotation of human genetic variants is important for some significant biomedical tasks like understanding functional genomics and gene-disease associations.
Emad S. Abouel Nasr, H. Al-Mubaid
doaj   +1 more source

Protein Function Prediction with Incomplete Annotations [PDF]

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2014
Automated protein function prediction is one of the grand challenges in computational biology. Multi-label learning is widely used to predict functions of proteins. Most of multi-label learning methods make prediction for unlabeled proteins under the assumption that the labeled proteins are completely annotated, i.e., without any missing functions ...
Guoxian, Yu, Huzefa, Rangwala, Carlotta, Domeniconi, Guoji, Zhang, Zhiwen, Yu   +4 more
openaire   +2 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Functional annotation of the animal genomes: An integrated annotation resource for the horse.

PLoS Genetics, 2023
The genomic sequence of the horse has been available since 2009, providing critical resources for discovering important genomic variants regarding both animal health and population structures.
Sichong Peng, Anna R Dahlgren, Callum G Donnelly, Erin N Hales, Jessica L Petersen, Rebecca R Bellone, Ted Kalbfleisch, Carrie J Finno   +7 more
doaj   +1 more source

Learning a Hybrid Architecture for Sequence Regression and Annotation

, 2015
When learning a hidden Markov model (HMM), sequen- tial observations can often be complemented by real-valued summary response variables generated from the path of hid- den states. Such settings arise in numerous domains, includ- ing many applications in
Carin, Lawrence, Hartemink, Alexander J., Henao, Ricardo, Zhang, Yizhe, Zhong, Jianling   +4 more
core   +2 more sources

Annotation-based inference of transporter function [PDF]

Bioinformatics, 2008
Abstract Motivation: We present a method for inferring and constructing transport reactions for transporter proteins based primarily on the analysis of the names of individual proteins in the genome annotation of an organism. Transport reactions are declarative descriptions of transporter activities, and thus can be manipulated ...
Lee, Thomas J., Paulsen, Ian, Karp, Peter   +2 more
openaire   +2 more sources