Results 41 to 50 of about 339,629 (251)

A functional annotation of subproteomes in human plasma [PDF]

PROTEOMICS, 2005
AbstractThe data collected by Human Proteome Organization's Plasma Proteome Pilot project phase was analyzed by members of our working group. Accordingly, a functional annotation of the human plasma proteome was carried out. Here, we report the findings of our analyses.
Ping, P., Vondriska, T. M., Creighton, Chad J., Gandhi, T. K. B., Yang, Ziping, Menon, Rajasree, Kwon, Min-Seok, Drwal, G., Kellman, M., Peri, S., Suresh, S., Gronborg, M., Molina, H., Chaerkady, R., Rekha, B., Muthusamy, B., Shet, A. S., Gerszten, R. E., Wu, Haifeng, Raftery, M., Wasinger, V., Schulze-Knappe, P., Hanash, Samir M., Paik, Young-Ki, Hancock, W. S., States, David J., Omenn, Gilbert S., Pandey, A.   +27 more
openaire   +3 more sources

Metagenomic annotation networks: construction and applications. [PDF]

PLoS ONE, 2012
The derivation and comparison of biological interaction networks are vital for understanding the functional capacity and hierarchical organization of integrated microbial communities.
Gregory Vey, Gabriel Moreno-Hagelsieb
doaj   +1 more source

Assessing the performance of different approaches for functional and taxonomic annotation of metagenomes

BMC Genomics, 2019
Background Metagenomes can be analysed using different approaches and tools. One of the most important distinctions is the way to perform taxonomic and functional assignment, choosing between the use of assembly algorithms or the direct analysis of raw ...
Javier Tamames, Marta Cobo-Simón, Fernando Puente-Sánchez   +2 more
doaj   +1 more source

Structural and functional annotation of the porcine immunome [PDF]

BMC Genomics, 2013
Abstract Background The domestic pig is known as an excellent model for human immunology and the two species share many pathogens. Susceptibility to infectious disease is one of the major constraints on swine performance, yet the structure and function of genes comprising the pig immunome are not well-characterized ...
Dawson, Harry D, Loveland, Jane E, Pascal, Géraldine, Gilbert, James G R, Uenishi, Hirohide, Mann, Katherine M, Sang, Yongming, Zhang, Jie, Carvalho-Silva, Denise, Hunt, Toby, Hardy, Matthew, Hu, Zhiliang, Zhao, Shu-Hong, Anselmo, Anna, Shinkai, Hiroki, Chen, Celine, Badaoui, Bouabid, Berman, Daniel, Amid, Clara, Kay, Mike, Lloyd, David, Snow, Catherine, Morozumi, Takeya, Cheng, Ryan Pei-Yen, Bystrom, Megan, Kapetanovic, Ronan, Schwartz, John C, Kataria, Ranjit, Astley, Matthew, Fritz, Eric, Steward, Charles, Thomas, Mark, Wilming, Laurens, Toki, Daisuke, Archibald, Alan L, Bed'Hom, Bertrand, Beraldi, Dario, Huang, Ting-Hua, Ait-Ali, Tahar, Blecha, Frank, Botti, Sara, Freeman, Tom C, Giuffra, Elisabetta, Hume, David A, Lunney, Joan K, Murtaugh, Michael P, Reecy, James M, Harrow, Jennifer L, Gaillard, Claire, Tuggle, Christopher K   +49 more
openaire   +8 more sources

Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology

RNA Biology
Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ...
Giulia Antonazzo, Pascale Gaudet, Ruth C. Lovering, Helen Attrill   +3 more
doaj   +1 more source

Assessment of genome annotation using gene function similarity within the gene neighborhood

BMC Bioinformatics, 2017
Background Functional annotation of bacterial genomes is an obligatory and crucially important step of information processing from the genome sequences into cellular mechanisms. However, there is a lack of computational methods to evaluate the quality of
Se-Ran Jun, Intawat Nookaew, Loren Hauser, Andrey Gorin   +3 more
doaj   +1 more source

DFLAT: functional annotation for human development [PDF]

BMC Bioinformatics, 2014
Recent increases in genomic studies of the developing human fetus and neonate have led to a need for widespread characterization of the functional roles of genes at different developmental stages. The Gene Ontology (GO), a valuable and widely-used resource for characterizing gene function, offers perhaps the most suitable functional annotation system ...
Heather C. Wick, Harold J. Drabkin, Huy Ngu, Michael Sackman, Craig Fournier, Jessica Haggett, Judith A. Blake, Diana W. Bianchi, Donna K. Slonim   +8 more
openaire   +3 more sources

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Functional Annotations of Paralogs: A Blessing and a Curse [PDF]

Life, 2016
Gene duplication followed by mutation is a classic mechanism of neofunctionalization, producing gene families with functional diversity. In some cases, a single point mutation is sufficient to change the substrate specificity and/or the chemistry performed by an enzyme, making it difficult to accurately separate enzymes with identical functions from ...
Rémi Zallot, Katherine Harrison, Bryan Kolaczkowski, Valérie De Crécy-Lagard   +3 more
openaire   +5 more sources

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source