Results 61 to 70 of about 361,695 (297)

GenDB - an open source genome annotation system for prokaryote genomes

, 2003
Meyer F, Goesmann A, McHardy AC, et al. GenDB - an open source genome annotation system for prokaryote genomes. Nucleic Acids Research.
Rupp, Oliver, Bartels, Daniela, Linke, Burkhard, McHardy, Alice C., Goesmann, Alexander ; https://orcid.org/, Bekel, Thomas, Kalinowski, Jörn, Giegerich, Robert, Pühler, Alfred ; https://orcid.org/, Meyer, Folker, Clausen, Jörn   +10 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Introducing a corpus of conversational stories. Construction and annotation of the Narrative Corpus [PDF]

, 2012
Although widely seen as critical both in terms of its frequency and its social significance as a prime means of encoding and perpetuating moral stance and configuring self and identity, conversational narrative has received little attention in corpus ...
O'Donnell, Matthew Brook, Rühlemann, Christoph   +1 more
core   +1 more source

Clinically Relevant Functional Annotation of Genotype [PDF]

Circulation: Cardiovascular Genetics, 2014
Genetic testing was originally thought likely to generate deterministic predictions of many clinical outcomes in inherited disorders. Indeed, this premise was one of the original drivers of the precision medicine movement. However, the variable expression of final phenotypes even in the setting of large genetic effects has long reinforced the ...
Calum A, MacRae, Ramachandran S, Vasan
openaire   +2 more sources

Functional Annotation Analytics of Genomes

Bioinformatics and Biology Insights, 2011
Rhodopseudomonas palustris , a nonsulphur purple photosynthetic bacteria, has been extensively investigated for its metabolic versatility including ability to produce hydrogen gas from sunlight and biomass.
Shaneka S. Simmons, Raphael D. Isokpehi, Shyretha D. Brown, Donee L. Mcallister, Charnia C. Hall, Wanaki M. Mcduffy, Tamara L. Medley, Udensi K. Udensi, Rajendram V. Rajnarayanan, Wellington K. Ayensu, Hari H.P. Cohly   +10 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

AGMIAL: implementing an annotation strategy for prokaryote genomes as a distributed system

, 2006
We have implemented a genome annotation system for prokaryotes called AGMIAL. Our approach embodies a number of key principles. First, expert manual annotators are seen as a critical component of the overall system; user interfaces were cyclically ...
Loux, Valentin, S. Chaillou, Hoebeke, Mark,, Maguin, Emmanuelle, K. Bryson, Loux, V., Chaillou, Stéphane, Bessières, P., Bessières, Philippe, Chaillou, Stephane,, Gibrat, J.-F., M. Van De Guchte, Chaillou, S., Gibrat, Jean-François, Hoebeke, M., Penaud, Stéphanie, van de Guchte, M., van de Guchte, Maarten,, Maguin, E., E. Maguin, Penaud, S., P. Nicolas, M. Hoebeke, van de Guchte, Maarten, Bossy, Robert,, Bryson, K., S. Penaud, V. Loux, Bossy, R., Bossy, Robert, R., R. Bossy, Hoebeke, Mark, J-f Gibrat, Nicolas, P.   +33 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

Functional domain annotation by structural similarity

NAR Genomics and Bioinformatics, 2023
Abstract Traditional automated in silico functional annotation uses tools like Pfam that rely on sequence similarities for domain annotation. However, structural conservation often exceeds sequence conservation, suggesting an untapped potential for improved annotation through structural similarity. This approach was previously overlooked
Poorya Mirzavand Borujeni, Reza Salavati
openaire   +2 more sources