Results 71 to 80 of about 563,469 (347)
Functional annotation of noncoding mutations in cancer
Life Science Alliance, 2021 Recurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples. In a cancer genome, the noncoding sequence contains the vast majority of somatic mutations.
Husen M Umer +3 more
doaj +1 more source
HAMAP in 2015: updates to the protein family classification and annotation system. [PDF]
, 2015 HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the automatic classification and annotation of protein sequences. HAMAP provides annotation of the same quality and detail as UniProtKB/
Auchincloss, A.H. +12 more
core +1 more source
PocketAnnotate: towards site-based function annotation [PDF]
Nucleic Acids Research, 2012 A computational pipeline PocketAnnotate for functional annotation of proteins at the level of binding sites has been proposed in this study. The pipeline integrates three in-house algorithms for site-based function annotation: PocketDepth, for prediction of binding sites in protein structures; PocketMatch, for rapid comparison of binding sites and ...
Anand, Praveen +2 more
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Protein Function Prediction with Incomplete Annotations [PDF]
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2014 Automated protein function prediction is one of the grand challenges in computational biology. Multi-label learning is widely used to predict functions of proteins. Most of multi-label learning methods make prediction for unlabeled proteins under the assumption that the labeled proteins are completely annotated, i.e., without any missing functions ...
Guoxian, Yu +4 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Functional Annotation and Analysis of Genetic Variants
IEEE Access, 2023 The process of functional annotation of human genetic variants is important for some significant biomedical tasks like understanding functional genomics and gene-disease associations.
Emad S. Abouel Nasr, H. Al-Mubaid
doaj +1 more source
Learning a Hybrid Architecture for Sequence Regression and Annotation
, 2015 When learning a hidden Markov model (HMM), sequen- tial observations can often be complemented by real-valued summary response variables generated from the path of hid- den states. Such settings arise in numerous domains, includ- ing many applications in
Carin, Lawrence +4 more
core +2 more sources
From treebank resources to LFG F-structures [PDF]
, 2003 We present two methods for automatically annotating treebank resources with functional structures. Both methods define systematic patterns of correspondence between partial PS configurations and functional structures.
A Cahill +10 more
core +1 more source
Annotation-based inference of transporter function [PDF]
Bioinformatics, 2008 Abstract Motivation: We present a method for inferring and constructing transport reactions for transporter proteins based primarily on the analysis of the names of individual proteins in the genome annotation of an organism. Transport reactions are declarative descriptions of transporter activities, and thus can be manipulated ...
Lee, Thomas J. +2 more
openaire +2 more sources