Results 91 to 100 of about 361,695 (297)

Integrative annotation of 21,037 human genes validated by full-length cDNA clones

open access: yes, 2004
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited.
Terwilliger Joseph D   +682 more
core   +1 more source

Annotation-based inference of transporter function [PDF]

open access: yesBioinformatics, 2008
Abstract Motivation: We present a method for inferring and constructing transport reactions for transporter proteins based primarily on the analysis of the names of individual proteins in the genome annotation of an organism. Transport reactions are declarative descriptions of transporter activities, and thus can be manipulated ...
Thomas J. Lee   +2 more
openaire   +2 more sources

Human gene correlation analysis (HGCA): A tool for the identification of transcriptionally co-expressed genes

open access: yesBMC Research Notes, 2012
Background Bioinformatics and high-throughput technologies such as microarray studies allow the measure of the expression levels of large numbers of genes simultaneously, thus helping us to understand the molecular mechanisms of various biological ...
Michalopoulos Ioannis   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Automatic F-Structure Annotation from the AP Treebank [PDF]

open access: yes, 2000
We present a method for automatically annotating treebank resources with functional structures. The method defines systematic patterns of correspondence between partial PS configurations and functional structures.
Sadler, Louisa   +2 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Automatic annotation of the Penn-treebank with LFG f-structure information [PDF]

open access: yes, 2002
Lexical-Functional Grammar f-structures are abstract syntactic representations approximating basic predicate-argument structure. Treebanks annotated with f-structure information are required as training resources for stochastic versions of unification ...
Cahill, Aoife   +3 more
core  

The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts

open access: yes, 2007
Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts.
Murakami, Katsuhiko   +300 more
core   +1 more source

Automatically extracting functionally equivalent proteins from SwissProt [PDF]

open access: yes, 2008
Background: There is a frequent need to obtain sets of functionally equivalent homologous proteins (FEPs) from different species. While it is usually the case that orthology implies functional equivalence, this is not always true; therefore datasets of ...
McMillan, LEM   +7 more
core   +1 more source

Functional annotation statistics

open access: yes, 2021
Functional annotation ...
chaiwat naktang (11438992)
core   +1 more source

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