Results 51 to 60 of about 563,469 (347)
Functional annotation strategy for protein structures [PDF]
Bioinformation, 2007 Whole-genome sequencing projects are a major source of unknown function proteins. However, as predicting protein function from sequence remains a difficult task, research groups recently started to use 3D protein structures and structural models to bypass it.
Olivia, Doppelt +3 more
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Non‐homology‐based prediction of gene functions in maize (Zea mays ssp. mays)
The Plant Genome, 2020 Advances in genome sequencing and annotation have eased the difficulty of identifying new gene sequences. Predicting the functions of these newly identified genes remains challenging.
Xiuru Dai +6 more
doaj +1 more source
DFLAT: functional annotation for human development [PDF]
BMC Bioinformatics, 2014 Recent increases in genomic studies of the developing human fetus and neonate have led to a need for widespread characterization of the functional roles of genes at different developmental stages. The Gene Ontology (GO), a valuable and widely-used resource for characterizing gene function, offers perhaps the most suitable functional annotation system ...
Wick, Heather C +8 more
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Annotation extension through protein family annotation coherence metrics
Frontiers in Genetics, 2013 Protein functional annotation consists in associating proteins with textual descriptors elucidating their biological roles. The bulk of annotation is done via automated procedures that ultimately rely on annotation transfer.
Hugo Paulo Bastos +2 more
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AnnotaPipeline: An integrated tool to annotate eukaryotic proteins using multi-omics data
Frontiers in Genetics, 2022 Assignment of gene function has been a crucial, laborious, and time-consuming step in genomics. Due to a variety of sequencing platforms that generates increasing amounts of data, manual annotation is no longer feasible. Thus, the need for an integrated,
Guilherme Augusto Maia +9 more
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Metagenomic annotation networks: construction and applications. [PDF]
PLoS ONE, 2012 The derivation and comparison of biological interaction networks are vital for understanding the functional capacity and hierarchical organization of integrated microbial communities.
Gregory Vey, Gabriel Moreno-Hagelsieb
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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]
, 2020 An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong +15 more
core
Functional domain annotation by structural similarity
NAR Genomics and Bioinformatics, 2023 Abstract Traditional automated in silico functional annotation uses tools like Pfam that rely on sequence similarities for domain annotation. However, structural conservation often exceeds sequence conservation, suggesting an untapped potential for improved annotation through structural similarity. This approach was previously overlooked
Poorya Mirzavand Borujeni, Reza Salavati
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BMC Research Notes, 2012 Abstract Functional annotation of every gene in the mouse genome is a herculean task that requires a multifaceted approach. Many large-scale initiatives are contributing to this undertaking. The International Knockout Mouse Consortium (IKMC) plans to mutate every protein-coding gene, using a combination of gene trapping and gene targeting in ...
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miRAnno—network-based functional microRNA annotation
Bioinformatics, 2021 Abstract Motivation Functional annotation is a common part of microRNA (miRNA)-related research, typically carried as pathway enrichment analysis of the selected miRNA targets. Here, we propose miRAnno, a fast and easy-to-use web application for miRNA annotation.
Tomas Tokar +4 more
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