Results 51 to 60 of about 3,702,794 (289)

Assessing the performance of different approaches for functional and taxonomic annotation of metagenomes

BMC Genomics, 2019
Background Metagenomes can be analysed using different approaches and tools. One of the most important distinctions is the way to perform taxonomic and functional assignment, choosing between the use of assembly algorithms or the direct analysis of raw ...
Javier Tamames, Marta Cobo-Simón, Fernando Puente-Sánchez   +2 more
doaj   +1 more source

Annotation extension through protein family annotation coherence metrics

Frontiers in Genetics, 2013
Protein functional annotation consists in associating proteins with textual descriptors elucidating their biological roles. The bulk of annotation is done via automated procedures that ultimately rely on annotation transfer.
Hugo Paulo Bastos, Luka Alexander Clarke, Francisco eCouto   +2 more
doaj   +1 more source

Functional annotation and ENU

BMC Research Notes, 2012
Abstract Functional annotation of every gene in the mouse genome is a herculean task that requires a multifaceted approach. Many large-scale initiatives are contributing to this undertaking. The International Knockout Mouse Consortium (IKMC) plans to mutate every protein-coding gene, using a combination of gene trapping and gene targeting in ...
openaire   +2 more sources

Metagenomic annotation networks: construction and applications. [PDF]

PLoS ONE, 2012
The derivation and comparison of biological interaction networks are vital for understanding the functional capacity and hierarchical organization of integrated microbial communities.
Gregory Vey, Gabriel Moreno-Hagelsieb
doaj   +1 more source

Functional Annotations of Paralogs: A Blessing and a Curse [PDF]

Life, 2016
Gene duplication followed by mutation is a classic mechanism of neofunctionalization, producing gene families with functional diversity. In some cases, a single point mutation is sufficient to change the substrate specificity and/or the chemistry performed by an enzyme, making it difficult to accurately separate enzymes with identical functions from ...
Rémi Zallot, Katherine Harrison, Bryan Kolaczkowski, Valérie De Crécy-Lagard   +3 more
openaire   +5 more sources

Clinically Relevant Functional Annotation of Genotype [PDF]

Circulation: Cardiovascular Genetics, 2014
Genetic testing was originally thought likely to generate deterministic predictions of many clinical outcomes in inherited disorders. Indeed, this premise was one of the original drivers of the precision medicine movement. However, the variable expression of final phenotypes even in the setting of large genetic effects has long reinforced the ...
Calum A, MacRae, Ramachandran S, Vasan
openaire   +2 more sources

Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology

RNA Biology
Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ...
Giulia Antonazzo, Pascale Gaudet, Ruth C. Lovering, Helen Attrill   +3 more
doaj   +1 more source

Assessment of genome annotation using gene function similarity within the gene neighborhood

BMC Bioinformatics, 2017
Background Functional annotation of bacterial genomes is an obligatory and crucially important step of information processing from the genome sequences into cellular mechanisms. However, there is a lack of computational methods to evaluate the quality of
Se-Ran Jun, Intawat Nookaew, Loren Hauser, Andrey Gorin   +3 more
doaj   +1 more source

The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts [PDF]

, 2007
Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts.
Murakami, Katsuhiko, Shionyu, Masafumi, Nagata, Naoki, Tanaka, S., Kuryshev, Vladimir, Eveno, E., Mukai, Yuri, Imbeaud, S., Makalowski, W., Zhang, Q., Sakai, Katsunaga, Thomas, Michaeｌ A., Imanishi, T., Lee, Kyung-Bum, Tanaka, Masayuki, Thomas, M.A., Barrero, Roberto, Osanger, A., Tanaka, Susumu, Lenhard, B., Shiba, Rie, Sugano, S., Sakate, Ryuichi, Nakai, K., Wilming, L., Jia, Libin, Kawamura, Toshiyuki, Nishikawa, T., Thierry-Mieg, J., Kawahara, Yoshihiro, Harada, E., Kimura, K., Suzuki, Yutaka, Tanaka, Nobuhiko, Yasuda, T., Kawamura, T., Sanbonmatsu, Ryoko, Barrero, R.A., Yamaguchi, Kaori, Hide, Winston, Auffray, C., Horton, Paul, Niimura, Y., Shimoyama, Mary, Thomas, Michael, Tonellato, Peter, Hilton, P.B., Kikuno, Reiko, Kanno, Masako, Sugawara, Hideaki, Isogai, T., Sakai, Hiroaki, Whitfield, Eleanor, Nishikata, K., Matsuya, Aki, Halligan, B., Ohtsubo, Masafumi, Shiba, R., Fukuchi, S., Lee, K-B, Takabayashi, K., Sakate, R., Nurimoto, S., Kaneko, Yayoi, Nagasaki, H., Hayashizaki, Yoshihide, Lin, Yi-Chueh, Bellgard, M., Minoshima, Shinsei, Motono, C., Amid, Clara, Schupp, Ingo, Osato, N., Wagner, L., Isogai, Takao, Ohyanagi, H., Yura, Kei, Akiyama, Y., Jia, Ji, Yamaguchi, K., O’Donovan, C., Endo, T., O'Donovan, C., Matsuya, Akihiro, Yamamoto, N., Jin, L., Hirakawa, M., Chun, Hong-Woo, Makino, Takashi, Thierry-Mieg, D., Jia, L., Tada, Masahito, Twigger, Simon, Jin, Ji, Zhang, Qinghua, Nurimoto, Shin, Tamura, T., Bonaldo, M.D.F., Todokoro, Fusano, Nozaki, A., Ohara, Osamu, De Souza, Sandro J., Hayakawa, Yosuke, Nagata, N., Koyanagi, K.O., Gojobori, T., Kim, N-S, Yamasaki, Chisato, Shimoyama, M., Makalowska, I., Yoo, H-S, Lancet, D., Imbeaud, Sandrine, Takeda, Jun, Sanbonmatsu, R., Nakai, Kenta, Debily, Anne, Yura, K., Shionyu, M., Todokoro, F., Ikeo, K., Osanger, Andreas, Hanaoka, Hideki, Tanino, Motohiko, Eveno, Eric, Estreicher, Anne, Nozaki, Asami, Sugano, Sumio, O'Donovan, Claire, De Souza, S.J., Bonaldo, Maria de Fatima, Kikuno, R., Murakami, K., Mukai, Y., Lancet, Doron, Hayakawa, Y., Lin, Y., Ogura Noda, Akiko, Hashizume, A., Kim, Nam-Soon, Takeda, J., Thierry-Mieg, Jean, Koyanagi, Kanako O., Mashima, J., Hilton, Phillip, Nakao, M., Saitou, N., Ohtsubo, M., Niimura, Yoshihito, Takahashi, Aiko, Nishikawa, K., Suzuki, Yoshiyuki, Habara, Takuya, Kikugawa, S., Han, Michael, Kuryshev, V., Tamura, Takuro, Shimada, M., Ohyanagi, Hajime, Tanino, M., Tateno, Y., Yamaguchi-Kabata, Y., Sato, Y., Suzuki, Mami, Ikeo, Kazuho, Chiusano, Maria Luisa, Lenhard, Boris, Go, Mitiko, Taniya, Takayuki, Itoh, Takeshi, Takahashi, A., Hinz, Ursula, Kikugawa, Shingo, Hide, Hideaki, Tanaka, M., Matsuya, A., Amid, C., Hirakawa, Mika, Debily, M.A., Akiyama, Yutaka, Suzuki, Y., Hishiki, T., Nomura, N., Koyanagi, Kanako, Fujii, Y., Hinz, U., Sugawara, H., Saitou, Naruya, Zhang, J., Chakraborty, R., Debily, Marie Anne, Wagner, Lukas, Noda, Aki, Sakai, H., Schupp, I., Nishikata, Ken, Hanaoka, H., Miyazaki, S., Kaneko, Y., Kim, S., Habara, T., Tanaka, N., Hishiki, Teruyoshi, Minoshima, S., Satake, Ryuichi, Nakai, Ken, Lin, Y-C, Bellgard, Matthew, Yoo, H., Suwa, M., Nishikawa, Tetsuo, Chun, H., Nagasaki, H, Okido, T., Wiemann, S., Kawahara, Y., Hayashizaki, Y., Barrero, Roberto A., Nishikata, Kensaku, Miyazaki, Satoru, Soares, Marcelo Bento, Han, M., Chen, Z., Kikugawa, Shin, Whitfield, E., Debily, M., Hide, W., Takabayashi, Kazuhiko, Fukuchi, Satoshi, Motono, Chie, Yoo, Hyang-Sook, Tada, M., Fujii, Yasuyuki, Nomura, Nobuo, Estreicher, A., Auffray, Charles, Gough, Craig, Tonellato, P., Wilming, Laurens, Mashima, Jun, Wiemann, Stefan, Ohara, O., Graudens, E., Hanada, Kousuke, Hashizume, Aki, Go, M., Zhang, Ji, Gough, C., Noda, A.O., Yasuda, Tomohiro, Chen, Zhu, Graudens, Esther, Nakao, Mitsuteru, Imanishi, Tadashi, Harada, Erimi, Kimura, Kouichi, Suwa, Makiko, Nagasaki, Hideki, Hilton, Philip B., Yamaguchi-Kabata, Yumi, Chiusano, M.L., Kulikova, T., Yamamoto, Naoyuki, Chakraborty, Ranajit, Saichi, Naomi, Kim, Sangsoo, Kulikova, Tamara, Makalowska, Izabela, Thierry-Mieg, Danielle, Suzuki, M., Taniya, T., Sakai, K., Okido, Toshihisa, Halligan, Brian, Chun, H-W, Twigger, S., De Souza, Sandro, Takeda, Jun-ichi, Yamasaki, C., Makino, T., Tiffin, Nicola, Nishikawa, Ken, Gojobori, Takashi, Kanno, M., Shimada, Makoto, Makalowski, Wojciech, Horton, P., Hanada, K., Tiffin, N., Osato, Naoki, Sato, Yoshiharu, Tateno, Yoshio, Saichi, N., Takeda, J-I, Jin, Lihua, Endo, Toshinori, Bonaldo, M., Soares, M.B., Itoh, T., Lee, K., Kim, N., K Murakami, T Imanishi, T Gojobori, Hyang Sook Yoo, Nam-Soon Kim, Y Sato, E Harada, J Takeda, Y Fujii, S Kim, C Yamasaki   +311 more
core   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source