Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species. [PDF]
Biology (Basel)Liu W +9 more
europepmc +3 more sources
Review on the Computational Genome Annotation of Sequences Obtained by Next-Generation Sequencing
Biology, 2020 Next-Generation Sequencing (NGS) has made it easier to obtain genome-wide sequence data and it has shifted the research focus into genome annotation. The challenging tasks involved in annotation rely on the currently available tools and techniques to ...
Girum Fitihamlak Ejigu, Jaehee Jung
doaj +1 more source
Biases in the Experimental Annotations of Protein Function and their Effect on Our Understanding of Protein Function Space [PDF]
, 2013 The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to protein sequence and structure data.
Babbitt, Patricia +5 more
core +4 more sources
Phylogenetic molecular function annotation
Journal of Physics: Conference Series, 2009 It is now easier to discover thousands of protein sequences in a new microbial genome than it is to biochemically characterize the specific activity of a single protein of unknown function. The molecular functions of protein sequences have typically been predicted using homology-based computational methods, which rely on the principle that homologous ...
Barbara E, Engelhardt +3 more
openaire +2 more sources
Towards Site-Based Protein Functional Annotations [PDF]
2008 IEEE International Conference on Bioinformatics and Biomedicine, 2008 The exact relationship between protein active centres and protein functions is unclear even after decades of intensive study. To improve functional prediction ability based on the local structures, we proposed three different methods. 1. We used Markov Random Field (MRF) to describe protein active region. 2. We developed filtering method that considers
Seak Fei, Lei, Jun, Huan
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Functional annotation of noncoding sequence variants [PDF]
Nature Methods, 2014 Identifying functionally relevant variants against the background of ubiquitous genetic variation is a major challenge in human genetics. For variants in protein-coding regions, our understanding of the genetic code and splicing allows us to identify likely candidates, but interpreting variants outside genic regions is more difficult.
Graham R S Ritchie +3 more
openaire +2 more sources
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. [PDF]
PLoS Genetics, 2006 The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched cDNAs.
Norihiro Maeda +33 more
doaj +2 more sources
Annotation Enrichment Analysis: An Alternative Method for Evaluating the Functional Properties of Gene Sets [PDF]
, 2013 Gene annotation databases (compendiums maintained by the scientific community that describe the biological functions performed by individual genes) are commonly used to evaluate the functional properties of experimentally derived gene sets.
Girvan, Michelle, Glass, Kimberly
core +2 more sources
Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
core +2 more sources
Re-annotation is an essential step in systems biology modeling of functional genomics data. [PDF]
PLoS ONE, 2010 One motivation of systems biology research is to understand gene functions and interactions from functional genomics data such as that derived from microarrays.
Bart H J van den Berg +3 more
doaj +1 more source