Results 101 to 110 of about 769,889 (306)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

iScience
Summary: During epithelial morphogenesis, in vivo, epithelial cells form cysts enclosing a single, hollow lumen and extend protrusions as a precursor for tubulogenesis.
Sydnie K. Tran, Jessanne Y. Lichtenberg, Corinne E. Leonard, Jessica R. Williamson, Hazel R. Sterling, Grace K. Panek, Amanda H. Pearson, Santiago Lopez, Christopher A. Lemmon, Daniel E. Conway, Priscilla Y. Hwang   +10 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity

iScience
Summary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome.
Gabriel Ruiz-Romero, María Dolores Berdún, Mark Hochstrasser, Silvia Salas-Pino, Rafael R. Daga   +4 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Visualizing dimensionality reduction of systems biology data

, 2012
One of the challenges in analyzing high-dimensional expression data is the detection of important biological signals. A common approach is to apply a dimension reduction method, such as principal component analysis. Typically, after application of such a
A Hyvaerinen, A Hyvaerinen, A Inselberg, A Inselberg, A Saeed, Albert Pritzkau, Andreas Lehrmann, Aydin C. Polatkan, DH Jeong, DJ Lockhart, F Battke, F Battke, GH Golub, H Abdi, H Hotelling, HF Kaiser, J Shendure, JB Tenenbaum, K Pearson, Kay Nieselt, KQ Weinberger, LK Saul, M Fontes, M Harrower, M Schena, Michael Huber, P Mannfolk, R Karbauskaite, R Tarjan, S Roweis, Z Zhang, Ö Altug-Teber   +31 more
core   +1 more source

Computational Cancer Biology: An Evolutionary Perspective [PDF]

, 2016
ISSN:1553-734XISSN:1553 ...
A Deutsch, A Fischer, A Gonzalez-Perez, A Roth, A Schuh, A Tofigh, A Trinh, AM Newman, BJ Raphael, C Guichard, C Tomasetti, C Tomasetti, CD Greenman, Chris D. Greenman, CO Nordling, CS Cooper, CS-O Attolini, E Purdom, E Szczurek, ER Fearon, F Michor, F Ronquist, F Strino, F Vandin, H Shahrabi Farahani, H Zare, I Bozic, I Bozic, I Martincorena, J Diaz, J Foo, J Rahnenführer, J Shendure, Jens Lagergren, JH Goldie, K Yuan, KI Kim, L Oesper, LJ Barber, LMF Merlo, LR Yates, M Consequences, M Gerlinger, M Gerstung, M Gerstung, M Gerstung, M Hjelm, M Kimmel, MDM Leiserson, MDM Leiserson, MDM Leiserson, MF Berger, MS Lawrence, N Beerenwinkel, N Beerenwinkel, N Beerenwinkel, N Crosetto, N Navin, NE Navin, Niko Beerenwinkel, P Armitage, P Eirew, P Haccou, PC Nowell, PS Larson, R Desper, R Durrett, RF Schwarz, Ruth Nussinov, S Constantinescu, S Nik-Zainal, S Nik-Zainal, S Turajlic, S Turajlic, SA Chowdhury, SA Chowdhury, SE Luria, T Sakoparnig, V Almendro, W Jiao, WJ Ewens, Y Iwasa   +81 more
core   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source