Results 101 to 110 of about 716,371 (239)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Clocks & SleepContinued solicitation of cognitive resources eventually leads to cognitive fatigue (CF), i.e., a decrease in cognitive efficiency that develops during sustained cognitive demands in conditions of constrained processing time, independently of sleepiness.
Oumaïma Benkirane +2 more
doaj +1 more source
Introducing Alternative-Based Thresholding for Defining Functional Regions of Interest in fMRI
Frontiers in Neuroscience, 2017 In fMRI research, one often aims to examine activation in specific functional regions of interest (fROIs). Current statistical methods tend to localize fROIs inconsistently, focusing on avoiding detection of false activation.
Jasper Degryse +5 more
doaj +1 more source
The Weekly Calendar Planning Activity to Assess Functional Cognition in Parkinson Disease. [PDF]
OTJR (Thorofare N J), 2022 Foster ER +5 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Intentional Cognitive Models with Volition
, 2006 Man’s intellectual capacity remains an enigma, as it is both the subject and the means of analysis. If one is to assume quantum-wave dualism in physics then the state of the world depends on the instruments we use for observation.
Howard, Newton, Qusaibaty, Ammar
core
Modeling Dynamic Functional Connectivity with Latent Factor Gaussian Processes [PDF]
, 2019 Dynamic functional connectivity, as measured by the time-varying covariance of neurological signals, is believed to play an important role in many aspects of cognition.
Baldi, Pierre +5 more
core +1 more source
Towards Parallel Selective Attention Using Psychophysiological States as the Basis for Functional Cognition. [PDF]
Sensors (Basel), 2022 Kanwal A +6 more
europepmc +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source