Results 61 to 70 of about 278,377 (300)

The Effect of Maternal Multiple Micronutrient Supplementation on Cognition and Mood during Pregnancy and Postpartum in Indonesia: A Randomized Trial [PDF]

, 2012
Maternal caregiving capacity, which is affected in part by cognition and mood, is crucial for the health of mothers and infants. Few interventions aim to improve maternal and infant health through improving such capacity.
SUMMIT Study Group, Michael T Ullman, Husni Muadz (179305), Prado, Elizabeth L., Katherine J Alcock, Husni Muadz, Alcock, Katherine J, Shankar, Anuraj H., Muadz, Husni, Anuraj H. Shankar (179306), Anuraj H Shankar, Prado, Elizabeth L, Alcock, Katherine J., Michael T. Ullman (179303), Elizabeth L Prado, Elizabeth L. Prado (179301), Shankar, Anuraj H, Ullman, Michael T., Ullman, Michael T, Katherine J. Alcock (114048)   +19 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cognitive Fatigue, Sleep and Cortical Activity in Multiple Sclerosis Disease. A Behavioral, Polysomnographic and Functional Near-Infrared Spectroscopy Investigation

Frontiers in Human Neuroscience, 2018
Patients with multiple sclerosis (MS) disease frequently experience fatigue as their most debilitating symptom. Fatigue in MS partially refers to a cognitive component, cognitive fatigue (CF), characterized by a faster and stronger than usual development
Guillermo Borragán, Guillermo Borragán, Médhi Gilson, Médhi Gilson, Anne Atas, Anne Atas, Hichem Slama, Hichem Slama, Hichem Slama, Hichem Slama, Andreas Lysandropoulos, Melanie De Schepper, Melanie De Schepper, Philippe Peigneux, Philippe Peigneux   +14 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mapping Cognitive Function [PDF]

Neuroimaging Clinics of North America, 2007
Cognitive functions are fundamental to being human. Although tremendous progress has been made in the science of cognition using neuroimaging, the clinical applications of neuroimaging are just beginning to be realized. This article focuses on selected technologies, analysis techniques, and applications that have, or will soon have, direct clinical ...
Steven M, Stufflebeam, Bruce R, Rosen
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional cognitive performance augments cognitive screening data in older adults

Frontiers in Aging Neuroscience
BackgroundUnderstanding the association of older adults’ cognitive ability with performance of instrumental activities of daily living (IADL) is critical to identifying their community health care support needs.
Timothy S. Marks, Gordon Muir Giles, Dorothy Farrar Edwards   +2 more
doaj   +1 more source

The cortical structure of functional networks associated with age-related cognitive abilities in older adults. [PDF]

PLoS ONE, 2018
Age and cortical structure are both associated with cognition, but characterizing this relationship remains a challenge. A popular approach is to use functional network organization of the cortex as an organizing principle for post-hoc interpretations of
Michael B Kranz, Michelle W Voss, Gillian E Cooke, Sarah E Banducci, Agnieszka Z Burzynska, Arthur F Kramer   +5 more
doaj   +1 more source