Results 71 to 80 of about 716,371 (239)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Functional cognitive performance augments cognitive screening data in older adults
Frontiers in Aging NeuroscienceBackgroundUnderstanding the association of older adults’ cognitive ability with performance of instrumental activities of daily living (IADL) is critical to identifying their community health care support needs.
Timothy S. Marks +2 more
doaj +1 more source
The evolutionary origins of volition [PDF]
, 2006 It appears to be a straightforward implication of distributed cognition principles that there is no integrated executive control system (e.g. Brooks 1991, Clark 1997). If distributed cognition is taken as a credible paradigm for cognitive science this in
Christensen, Dr Wayne
core
Episodic memory retrieval, parietal cortex, and the default mode network: Functional and topographic analyses [PDF]
, 2011 The default mode network (DMN) is often considered a functionally homogeneous system that is broadly associated with internally directed cognition (e.g., episodic memory, theory of mind, self-evaluation).
Corbetta, Maurizio +3 more
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The effect of geometer sketchpad on secondary school students’ mathematical intelligence
Frontiers in EducationIn recent years, the impact of teaching technology on students’ mathematical intelligence has received essential academic attention. Students’ mathematical intelligence is a crucial criterion to measure their mathematical understanding and problem ...
Yu Fei Ma
doaj +1 more source
Brain aging differs with cognitive ability regardless of education
Scientific Reports, 2022 Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e.
Kristine B. Walhovd +19 more
doaj +1 more source
Investigating White Matter Lesion Load, Intrinsic Functional Connectivity, and Cognitive Abilities in Older Adults [PDF]
, 2020 Changes to the while matter of the brain disrupt neural communication between spatially distributed brain regions and are associated with cognitive changes in later life.
Kantarovich, Karin
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Trait paranoia shapes inter-subject synchrony in brain activity during an ambiguous social narrative
Nature Communications, 2018 Reactions to the same event can vary vastly based on multiple factors. Here the authors show that people with high trait-level paranoia process ambiguous information in a narrative differently and this can be attributed to greater activity in mentalizing
Emily S. Finn +4 more
doaj +1 more source