Results 71 to 80 of about 278,377 (300)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The effect of geometer sketchpad on secondary school students’ mathematical intelligence

Frontiers in Education
In recent years, the impact of teaching technology on students’ mathematical intelligence has received essential academic attention. Students’ mathematical intelligence is a crucial criterion to measure their mathematical understanding and problem ...
Yu Fei Ma
doaj   +1 more source

Lack of power enhances visual perceptual discrimination [PDF]

, 2011
Powerless individuals face much challenge and uncertainty. As a consequence, they are highly vigilant and closely scrutinize their social environments. The aim of the present research was to determine whether these qualities enhance performance in more ...
Ana Guinote, Guinote, A., Wilkinson, D.T., Weick, M., David Wilkinson, Weick, Mario, Wilkinson, David T., Mario Weick, Guinote, Ana   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Post-mortem 11.7 Tesla Magnetic Resonance Imaging vs. Polarized Light Imaging Microscopy to Measure the Angle and Orientation of Dorsal Root Afferents in the Human Cervical Dorsal Root Entry Zone

Frontiers in Neuroanatomy, 2019
Background: Destruction of the afferents by dorsal root entry zone (DREZ) surgery may be an effective treatment of intractable neuropathic pain, though it remains a high-risk surgical intervention.
Dylan Jozef Hendrik Augustinus Henssen, Dylan Jozef Hendrik Augustinus Henssen, Rosanna Christina Weber, Jesse de Boef, Jeroen Mollink, Jeroen Mollink, Tamas Kozicz, Erkan Kurt, Anne-Marie van Cappellen van Walsum   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Neuroscience and Phenomenology [PDF]

, 2011
This text contributes to a necessary dialogue, and possibly a translation of the different notions employed by neuroscience and phenomenology. This effort is particularly significant for cognitive neuroscientists whose main topic is social cognition ...
Gallese, Vittorio
core  

General Collective Intelligence, Human-Centric Functional Modeling and the Current Limitations on Collective Design Cognition

, 2020
This paper explores the limits to the size and complexity of designs that can be created by humans. Beginning with the existence of a finite limit to the design output of any single individual, as a result, some design efforts require teams.
Williams, Andy
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Trait paranoia shapes inter-subject synchrony in brain activity during an ambiguous social narrative

Nature Communications, 2018
Reactions to the same event can vary vastly based on multiple factors. Here the authors show that people with high trait-level paranoia process ambiguous information in a narrative differently and this can be attributed to greater activity in mentalizing
Emily S. Finn, Philip R. Corlett, Gang Chen, Peter A. Bandettini, R. Todd Constable   +4 more
doaj   +1 more source