Results 111 to 120 of about 33,300,374 (339)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
LIFT: A functional data-parallel IR for high-performance GPU code generation
IEEE/ACM International Symposium on Code Generation and Optimization, 2017 Parallel patterns (e.g., map, reduce) have gained traction as an abstraction for targeting parallel accelerators and are a promising answer to the performance portability problem.
Michel Steuwer +2 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Dependence Modeling, 2018 The main objective of this paper is to non-parametrically estimate the quantiles of a conditional distribution in the censorship model when the sample is considered as an -mixing sequence.
Kadiri Nadia +2 more
doaj +1 more source
On the concept of depth for functional data [PDF]
, 2006 The statistical analysis of functional data is a growing need in many research areas. We propose a new depth notion for functional observations based on the graphic representation of the curves. Given a collection of functions, it allows to establish the
López Pintado, Sara, Romo, Juan
core +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Detection of Anomalies in Water Networks by Functional Data Analysis
Mathematical Problems in Engineering, 2018 A functional data analysis (FDA) based methodology for detecting anomalous flows in urban water networks is introduced. Primary hydraulic variables are recorded in real-time by telecontrol systems, so they are functional data (FD).
Laura Millán-Roures +2 more
semanticscholar +1 more source