Results 101 to 110 of about 3,633,355 (289)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Probing ADP Induced Aggregation Kinetics During Platelet-Nanoparticle Interactions: Functional Dynamics Analysis to Rationalize Safety and Benefits

Frontiers in Bioengineering and Biotechnology, 2019
Platelets, one of the most sensitive blood cells, can be activated by a range of external and internal stimuli including physical, chemical, physiological, and/or non-physiological agents.
Souvik K. Bandyopadhyay, Mohammad Azharuddin, Anjan K. Dasgupta, Bhaswati Ganguli, Sugata SenRoy, Hirak K. Patra, Hirak K. Patra, Hirak K. Patra, Suryyani Deb   +8 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Setting a generalized functional linear model (GFLM) for the classification of different types of cancer

Latin-American Journal of Computing, 2016
This work aims to classify the DNA sequences of healthy and malignant cancer respectively. For this, supervised and unsupervised classification methods from a functional context are used; i.e. each strand of DNA is an observation.
Miguel Flores, Guido Saltos, Sergio Castillo Páez   +2 more
doaj  

Diagnosis of Mechanical Rotor Faults in Drones Using Functional Gaussian Mixture Classifier

Aerospace
The article presents the topic of propeller damage detection on unmanned multirotor drones. Propeller damage is dangerous as it can negatively affect the flight of a drone or lead to hazardous situations.
Bartosz Bartoszewski, Kacper Jarzyna, Jerzy Baranowski   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Improved Discontinuous Lyapunov Functionals for Stability Analysis of Sampled-Data Systems [PDF]

, 2021
Binh Nguyen, Sung Hyun Kim
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment

Frontiers in Aging Neuroscience
BackgroundReduced heart rate variability (HRV) has been associated with cognitive decline in older adults. However, prior research relied on brief in-clinic electrocardiography (ECG) recordings to measure HRV.
Jiyue Qin, Jiyue Qin, Carol A. Derby, Carol A. Derby, Grace Liu, Cuiling Wang, Richard P. Sloan, Richard P. Sloan   +7 more
doaj   +1 more source