Results 121 to 130 of about 3,338,515 (259)

Verified Analysis of Functional Data Structures.

, 2016
In recent work the author has analyzed a number of classical functional search tree and priority queue implementations with the help of the theorem prover Isabelle/HOL. The functional correctness proofs of AVL trees, red-black trees, 2-3 trees, 2-3-4 trees, 1-2 brother trees, AA trees and splay trees could be automated.
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional data analysis of lower-limb joint kinematics during badminton lunges under fatigue. [PDF]

Front Bioeng Biotechnol
Fang Y, Zhang X, Sun Y, Wu H, Pei H, Gao J, Liu J, Zhu Q, Gao Y.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Beyond Static Assessment: A Proof-of-Concept Evaluation of Functional Data Analysis for Assessing Physiological Responses to High-Intensity Effort. [PDF]

J Funct Morphol Kinesiol
Odriozola A, Tirnauca C, González A, Corbi F, Álvarez-Herms J.   +4 more
europepmc   +1 more source

Functional Data Analysis for Predicting Pediatric Failure to Complete Ten Brief Exercise Bouts. [PDF]

IEEE J Biomed Health Inform, 2022
Coronato N, Brown DE, Sharma Y, Bar-Yoseph R, Radom-Aizik S, Cooper DM.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Insights into Neuromuscular Function in Older Adults from Functional Data Analysis of Time-Dependent Handgrip Strength Curves. [PDF]

Bioengineering (Basel)
Urbano D, Inácio M, Restivo MT.
europepmc   +1 more source

Functional data analysis of the relationship between electricity consumption and climate change drivers. [PDF]

J Appl Stat, 2023
Elayouty A, Abou-Ali H.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source