FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis. [PDF]
Sci Rep, 2023 Matabuena M +5 more
europepmc +1 more source
Verified Analysis of Functional Data Structures.
, 2016 In recent work the author has analyzed a number of classical functional search tree and priority queue implementations with the help of the theorem prover Isabelle/HOL. The functional correctness proofs of AVL trees, red-black trees, 2-3 trees, 2-3-4 trees, 1-2 brother trees, AA trees and splay trees could be automated.
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Functional data analysis of lower-limb joint kinematics during badminton lunges under fatigue. [PDF]
Front Bioeng BiotechnolFang Y +8 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Insights into Neuromuscular Function in Older Adults from Functional Data Analysis of Time-Dependent Handgrip Strength Curves. [PDF]
Bioengineering (Basel)Urbano D, Inácio M, Restivo MT.
europepmc +1 more source
Functional Data Analysis for Predicting Pediatric Failure to Complete Ten Brief Exercise Bouts. [PDF]
IEEE J Biomed Health Inform, 2022 Coronato N +5 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Beyond Static Assessment: A Proof-of-Concept Evaluation of Functional Data Analysis for Assessing Physiological Responses to High-Intensity Effort. [PDF]
J Funct Morphol KinesiolOdriozola A +4 more
europepmc +1 more source