Results 71 to 80 of about 3,232,072 (306)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Bayesian Functional Data Analysis in Astronomy

Physical Sciences Forum
Cosmic demographics—the statistical study of populations of astrophysical objects—has long relied on tools from multivariate statistics for analyzing data comprising fixed-length vectors of properties of objects, as might be compiled in a tabular ...
Thomas Loredo, Tamás Budavári, David Kent, David Ruppert   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

EXPLORATORY ANALYSIS OF REGIONALIZED VARIABLES WITH FUNCTIONAL METHODS ANÁLISIS EXPLORATORIO DE VARIABLES REGIONALIZADAS CON MÉTODOS FUNCIONALES

Revista Colombiana de Estadística, 2007
It is shown how summary statistics of functional data and functional principal components analysis (FPCA) can be used to evaluate the stationarity assumption considered in modeling of regionalized variables.
Giraldo Ramón
doaj  

Probing ADP Induced Aggregation Kinetics During Platelet-Nanoparticle Interactions: Functional Dynamics Analysis to Rationalize Safety and Benefits

Frontiers in Bioengineering and Biotechnology, 2019
Platelets, one of the most sensitive blood cells, can be activated by a range of external and internal stimuli including physical, chemical, physiological, and/or non-physiological agents.
Souvik K. Bandyopadhyay, Mohammad Azharuddin, Anjan K. Dasgupta, Bhaswati Ganguli, Sugata SenRoy, Hirak K. Patra, Hirak K. Patra, Hirak K. Patra, Suryyani Deb   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

RAW DATA for Analysis of Proteoglycan 4 mRNA Expression on Pain Improvement and Functional Ability in Knee Osteoarthritis Patients After High-Intensity Laser Administration

, 2023
Mohammad Adib Khumaidi, Fahrul Nurkolis
openalex   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Assessing biodiversity profile through FDA

Statistica, 2013
The past few years have highlighted the need to protect diversity in its broader concept and, in particular, with reference to the ecological context for environmental protection.
Tonio Di Battista, Francesca Fortuna
doaj   +1 more source