Results 121 to 130 of about 1,541,674 (284)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Functional Status in Relation to Common Geriatric Syndromes and Sociodemographic Variables – A Step Forward Towards Healthy Aging

Clinical Interventions in Aging
Lana Alhalaseh,1,* Hala Makahleh,1,* Bashayer Al-Saleem,1,* Farah Al-Omran,1,* Birgitte Schoenmakers2,* 1Department of Family and Community Medicine, School of Medicine, The University of Jordan, Amman, Jordan; 2Department of Public ...
Alhalaseh L, Makahleh H, Al-Saleem B, Al-Omran F, Schoenmakers B   +4 more
doaj  

The 2019 national health survey: what does it teach us about the epidemiological profile of stroke in Brazil?

BMC Public Health
Background Stroke is one of the leading causes of death in Brazil, as well as a major cause of disability in the population. Because of this, national surveys are highly relevant for understanding the impact and planning public policies.
Jussara Almeida de Oliveira Baggio, Bruna Roberta Lopes do Nascimento, Ariana Figueiredo Suassuna, Lucas Almeida Andrade, Marcio Bezerra-Santos, Letícia Januzi de Almeida Rocha   +5 more
doaj   +1 more source

Do age and functional dependence affect outcomes of simultaneous heart-kidney transplantation? [PDF]

JTCVS Open, 2023
Feng I, Kurlansky PA, Ning Y, Sun J, Naka Y, Topkara VK, Latif F, Sayer G, Uriel NY, Takeda K.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Functional dependence [PDF]

Transactions of the American Mathematical Society, 1935
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discussion to: Do age and functional dependence affect outcomes of simultaneous heart-kidney transplantation? [PDF]

JTCVS Open, 2023
Takeda K, Feng I, Pagani FD.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Persisting Short or Long Sleep Duration Predicts Post-Stroke Depression One year After Stroke and Transient Ischemic Attack

Nature and Science of Sleep
Yang Hu,1,* Lijun Zuo,1,* Yuesong Pan,2 Hongyi Yan,2 Yongjun Wang,1 Xingquan Zhao1 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2National Clinical Research Center for
Hu Y, Zuo L, Pan Y, Yan H, Wang Y, Zhao X   +5 more
doaj