Results 51 to 60 of about 273,540 (290)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Characterization of order-like dependencies with formal concept analysis [PDF]

, 2011
Functional Dependencies (FDs) play a key role in many fields of the relational database model, one of the most widely used database systems. FDs have also been applied in data analysis, data quality, knowl- edge discovery and the like, but in a very ...
Baixeries i Juvillà, Jaume, Codocedo, Victor, Kaytoue, Mehdi, Napoli, Amedeo   +3 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A malware detection method with function parameters encoding and function dependency modeling [PDF]

PeerJ Computer Science
As computers are widely used in people’s work and daily lives, malware has become an increasing threat to network security. Although researchers have introduced traditional machine learning and deep learning methods to conduct extensive research on ...
Ronghao Hou, Dongjie Liu, Xiaobo Jin, Jian Weng, Guanggang Geng   +4 more
doaj   +2 more sources

Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex

Communications Biology, 2023
One of the most well-established tools for modeling the brain is the functional connectivity network, which is constructed from pairs of interacting brain regions.
Thomas F. Varley, Maria Pope, Joshua Faskowitz, Olaf Sporns   +3 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

On the Family of Conditional Embedded Implicational Dependencies [PDF]

Computer Science Journal of Moldova, 1996
Certain second-order sentences, called conditional embedded implicational dependencies, about relations in a relational database, are defined and studied. This class of dependencies includes some of previously defined dependencies as special cases. Thus,
Victor Felea
doaj  

Multi-genome metabolic modeling predicts functional inter-dependencies in the Arabidopsis root microbiome

Microbiome, 2022
Background From a theoretical ecology point of view, microbiomes are far more complex than expected. Besides competition and competitive exclusion, cooperative microbe-microbe interactions have to be carefully considered.
Alice Mataigne, Nathan Vannier, Philippe Vandenkoornhuyse, Stéphane Hacquard   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source