Results 121 to 130 of about 5,235,169 (235)

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

MedComm, Volume 7, Issue 4, April 2026.
Ipriflavone (Ipr), an active component of Aquilaria malaccensis Lam. exosome‐like nanoparticles (AELNs), significantly reduces hypoxia‐inducible factor‐α (HIF‐α) expression by enhancing the prolyl hydroxylase domain protein 2 (PHD2)‐mediated hydroxylation of HIF‐α, thereby downregulating HIF‐α‐induced polyunsaturated fatty acid‐phospholipids (PUFA‐PLs),
Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng   +15 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Clinical Effectiveness of Rikkunshito in Neonates With Radiologically Confirmed Gastroesophageal Reflux Disease and Gastric Volvulus

Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
This retrospective study demonstrates the therapeutic efficacy of Rikkunshito in neonates with radiologically confirmed gastric volvulus or gastroesophageal reflux disease. Rikkunshito treatment significantly improved weight gain and vomiting frequency without serious adverse events, suggesting it is a safe and effective pharmacologic option.
Toshihiro Nakayama, Shonosuke Nara, Naofumi Hanyu, Midori Nishibata, Maria Nishibukuro, Hiroyuki Koga, Takashi Yamazaki, Gaku Yamanaka   +7 more
wiley   +1 more source

Avoidant‐Restrictive Food Intake Disorder in Patients With Gastrointestinal Disorders: A Systematic Review

Journal of Human Nutrition and Dietetics, Volume 39, Issue 2, April 2026.
ABSTRACT Introduction Avoidant‐restrictive food intake disorder (ARFID) is an eating disorder diagnosis implemented with DSM‐5 in 2013. Elevated risk for ARFID in patients with gastrointestinal disorders is suggested. This systematic review explored (1) methods used to identify patients with gastrointestinal disorders and comorbid ARFID and (2) their ...
Sissel Bekker Henriksen, Christina Hornemann, Ditte Roth Hulgaard   +2 more
wiley   +1 more source

Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study

Frontiers in Neurology
BackgroundTo investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization.MethodsData for major depression and functional dyspepsia were obtained from genome-wide association studies.
Yaming Du, Rui Wang, Rui Wang, Xinzi Xu, Junli Wang, Wei Shao, Guohua Chen, Guohua Chen   +7 more
doaj   +1 more source

Prevalence and Factors Associated With Symptom Profiles of Disorders of Gut‐Brain Interaction in Obesity Before and After Treatment

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
DGBI symptoms are common in obesity and have the potential to exacerbate negative health outcomes. In general, the prevalence of DGBI symptoms decreases after obesity treatment, but patients can also shift from one GI symptom profile to another. ABSTRACT Background & Aims Disorders of gut‐brain interaction (DGBI) in obesity could impair health outcomes.
Esther Colomier, Janita Halminen, Malin Björck, Gudrún Höskuldsdóttir, Karin Mossberg, My Engström, Björn Eliasson, Ville Wallenius, Lars Fändriks, Jan Tack, Hans Törnblom, Magnus Simrén   +11 more
wiley   +1 more source

Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
Anesthesia can alter measurements during digestive endoscopies, yet no standardized protocol currently exists. Two expert groups—the French Neuro‐Gastroenterology Group (GFNG) and anesthesiologists—used the Delphi method to reach a consensus on which drugs have an influence (91 amendments), ultimately resulting in a proposed anesthesia protocol (28 ...
Domitille Renard, Thomas Clavier, Osama Abou‐Arab, Gérard Amarenco, Emmanuel Besnier, Alice Blet, Matthieu Boisson, Charlène Brochard, Benoit Coffin, Audrey De Jong, Denis Frasca, Marc Garnier, Aurelie Gouel, Jérémie Jacques, Arthur James, Yoann Launey, Anne‐Marie Leroi, Chloé Melchior, Daphné Michelet, François Mion, Maxime Nguyen, Emmanuel Rineau, Amélie Rollé, Sabine Roman, Stéphanie Sigaut, Heithem Soliman, Fabien Wuestenberghs, Frank Zerbib, Guillaume Gourcerol, Charlotte Desprez   +29 more
wiley   +1 more source

Avoidant‐Restrictive Food Intake Disorder Is Common in Adults With Cyclic Vomiting Syndrome and Is Associated With Malnutrition

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
One in three adults with CVS were found to have a positive screen for ARFID. Most patients at risk of ARFID (NIAS+) had evidence of malnutrition and micronutrient deficiency. We recommend routine screening of patients with CVS for ARFID and referral to a registered dietitian to optimize clinical outcomes. ABSTRACT Background In cyclic vomiting syndrome
Thangam Venkatesan, Praveen S. Goday, Saranya Arumugam, Kebire Gofar, Mahima Vyas, Ana Petrova, Raul Jimenez‐Castillo, Muhammad Ayyan, Sonali Srivastava, Kristen Heitman, Peter Madril, Kristin Goheen, Kristen M. Roberts   +12 more
wiley   +1 more source

Experience of Maltreatment Is Associated With Abdominal Pain Intensity and Health‐Related Quality of Life in Children With Pain‐Predominant Disorders of Gut‐Brain Interaction

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
Adverse childhood experiences (ACEs) due to maltreatment were significantly associated with greater 7 day average abdominal pain intensity, poorer health‐related quality of life, greater anxiety, and greater depressive symptoms, while ACEs due to household challenges and social context were not significantly associated.
Molly P. Barr, Tolulope Adetayo, Corinne T. Evans, Emily O. Wakefield, Reed A. Dimmitt, Burel R. Goodin   +5 more
wiley   +1 more source

Pyloric Metrics and Distensibility Plateau by Functional Luminal Imaging Probe in Pediatric Patients: A Pilot Study

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
Pediatric patients underwent pyloric functional luminal imaging probe (FLIP) for refractory upper gastrointestinal symptoms. Unlike prior adult studies, pyloric distensibility did not correlate to gastric emptying, and patients with higher distensibility more frequently responded to botulinum toxin. The presence of a distensibility plateau enhanced the
Peter T. Osgood, Natalie V. Hoffmann, Joshua B. Wechsler, Roman Pantazopoulos, John E. Fortunato   +4 more
wiley   +1 more source