Results 81 to 90 of about 1,098,671 (288)

Orthogonal Stability and Solution of a Three-Variable Functional Equation in Extended Banach Spaces

Mathematics
This manuscript introduces a novel three-variable cubic functional equation and derives its general solution. Employing both the direct and fixed-point methods, we investigate the orthogonal stability of this equation within the frameworks of quasi-β ...
Jagjeet Jakhar, Shalu Sharma, Jyotsana Jakhar, Majeed A. Yousif, Pshtiwan Othman Mohammed, Alina Alb Lupas, Nejmeddine Chorfi   +6 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Noninformative Prior on a Space of Distribution Functions

Entropy, 2017
In a given problem, the Bayesian statistical paradigm requires the specification of a prior distribution that quantifies relevant information about the unknowns of main interest external to the data.
Alexander Terenin, David Draper
doaj   +1 more source

Lifting of the Vlasov-Maxwell Bracket by Lie-transform Method

, 2016
The Vlasov-Maxwell equations possess a Hamiltonian structure expressed in terms of a Hamiltonian functional and a functional bracket. In the present paper, the transformation ("lift") of the Vlasov-Maxwell bracket induced by the dynamical reduction of ...
Brizard, A. J., Burby, J. W., de Guillebon, L., Morrison, P. J., Vittot, M.   +4 more
core   +3 more sources

Eigenvalues and Functional Equations [PDF]

Proceedings of the American Mathematical Society, 1957
Abstract : The purpose of this paper was to illustrate how the techniques of the theory of dynamic programming may be used to convert a number of eigenvalue problems, where one is interested only in maximum or minimum values, into problems involving recurrence relations.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A numerical technique based on Lucas polynomials together with standard and Chebyshev-Lobatto collocation points for solving functional integro-differential equations involving variable delays

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
In this paper, a new numerical matrix-collocation technique is consideredto solve functional integro-differential equations involving variable delaysunder the initial conditions.
Sevin Gümgüm, Nurcan Baykuş Savaşaneril, Ömür Kıvanç Kürkçü, Mehmet Sezer   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Properties of a Composite Material with Mixed Imperfect Contact Conditions

Mathematical Modelling and Analysis, 2016
We present an analytical solution of a mixed boundary value problem for an unbounded 2D doubly periodic domain which is a model of a composite material with mixed imperfect interface conditions.
Luıs Filipe Pinheiro de Castro, Ekaterina Pesetskaya   +1 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source