Results 61 to 70 of about 60,168 (264)
Cross-Coupled Charge Pump Synthesis Based on Full Transistor-Level
Advances in Electrical and Electronic Engineering, 2019 This paper presents utility for the design of the cross-coupled charge pump, which is used for supplying peripherals with low current consumption on the chip, as the EEPROM or FLASH memories.
Jan Marek, Jiri Hospodka, Ondrej Subrt
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Надежность и качество сложных систем, 2021 Background. Traditional methods for assessing and analyzing the indicators of the durability of equipment of complex systems are based on the description of systems in time at the level of trajectories of behavior, and are idealizations, since they do ...
V.A. Ostreykovskiy, S.A. Lysenkova
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PFD Calculation Considering Imperfect Proof Tests
Chemical Engineering Transactions, 2016 The current state of the art in process and plant safety for the process industries with means of process control technology (PCT) follows the concepts of functional safety as denoted in IEC 61511-1 (2003).
Thomas Gabriel +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
MicromachinesThe positioning accuracy of the end effector is the core index that affects the robot’s performance. However, to achieve lightweight and functional requirements, the construction of end effectors is becoming more complex.
Changqi Li +5 more
doaj +1 more source
INCREASING CONTROL’S EFFICIENCY FOR THE SHIP’S TWO-MASS ELECTRIC DRIVE
Electrical engineering & Electromechanics, 2016 Purpose. For shipboard lifting and transporting machinery (LTM) with AC thyristor electric drives (ED) the problem of minimizing sway through the formation of the special law to change the principle of ED control over the lifting process is solved ...
V.V. Budashko
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source