Results 71 to 80 of about 71,517 (254)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Real-world study of efgartigimod in AChR antibody-positive generalized myasthenia gravis: thymus status, multi-domain symptom improvement and steroid-sparing effect

Frontiers in Immunology
BackgroundEfgartigimod has been approved for the treatment of gMG. However, real-world evidence regarding its efficacy across various functional domains in patients with differing thymic statuses, as well as its steroid-sparing effect when used in ...
Kariman Aili, Kariman Aili, Mingjia Lu, Mingjia Lu, Na Zhao, Na Zhao, Mayinuer Maimaiti, Mayinuer Maimaiti   +7 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Recovering Holomorphic Functions from Their Real or Imaginary Parts without the Cauchy--Riemann Equations [PDF]

SIAM Review, 2004
Summary: Students of elementary complex analysis usually begin by seeing the derivation of the Cauchy--Riemann equations. A topic of interest to both the development of the theory and its applications is the reconstruction of a holomorphic function from its real part, or the extraction of the imaginary part from the real part, or vice versa.
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Neural Network Method of Controllers’ Parametric Optimization with Variable Structure and Semi-Permanent Integration Based on the Computation of Second-Order Sensitivity Functions

Applied Sciences
This article presents a method for researching processes in automatic control systems based on the operator approach for modelling the control object and the controller. Within the method framework, a system of equations has been developed that describes
Serhii Vladov, Lukasz Scislo, Nina Szczepanik-Ścisło, Anatoliy Sachenko, Victoria Vysotska   +4 more
doaj   +1 more source

The rate of increase of real continuous solutions of certain algebraic functional equations [PDF]

Transactions of the American Mathematical Society, 1959
In this equation, and throughout this paper, P(t, u, v) denotes a polynomial in the variables t, u, v, with real coefficients, and b(t) is a function which is positive and continuous for t greater than or equal to some positive number a. The results presented below generalize those of 0. E. Lancaster [4], and S. M.
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

SMT and Functional Equation Solving over the Reals: Challenges from the IMO

Abstract We use SMT technology to address a class of problems involving uninterpreted functions and nonlinear real arithmetic. In particular, we focus on problems commonly found in mathematical competitions, such as the International Mathematical Olympiad (IMO), where the task is to determine all solutions to constraints on an ...
Chad E. Brown, Karel Chvalovský, Mikoláš Janota, Mirek Olšák, Stefan Ratschan   +4 more
openaire   +2 more sources