Results 81 to 90 of about 58,526 (297)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A maximal theorem for holomorphic semigroups. [PDF]

, 2004
Let X be a closed linear subspace of the Lebesgue space L^p(Omega ; mu); let -A be an invertible linear operator that is the generator of abounded holomorphic semigroup T_t on X.
Ian Doust, Doust, Ian, Gordon Blower, Blower, Gordon   +3 more
core  

Real-time correlation functions in the O(N) model from the functional renormalization group [PDF]

, 2014
In the framework of the functional renormalization group we present a simple truncation scheme for the computation of real-time mesonic $$n$$-point functions, consistent with the derivative expansion of the effective action.
von Smekal, Lorenz, Kamikado, Kazuhiko, Wambach, Jochen, Nils Strodthoff, Kazuhiko Kamikado, Strodthoff, Nils, Jochen Wambach, Lorenz von Smekal   +7 more
core   +1 more source

On Infinitesimal L_ω-smooth Functions.

Zanco Journal of Pure and Applied Sciences, 2022
The aim of this paper is to study smoothness, approximate continuity, and approximate derivative in a nonstandard manner with respect to infinitesimal parameters.
Ibrahim O. Hamad
doaj  

Synthesis of evasive maneuver control of unmanned aerial vehicle for terminal restrictions

Advanced Engineering Research, 2018
Introduction. The solution to the problem of development of suboptimal evasive strategy of unmanned aerial vehicle (UAV) under the conditions of uncertainty of the current motion characteristics, and the future behavior strategy of the interdictor is ...
N. Y. Polovinchuk, S. V. Ivanov, L. I. Kotelnitskaya   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Elementary evolutions in Banach algebra [PDF]

, 2013
An elementary class of evolutions in unital Banach algebras is obtained by integrating product functions over Guichardet's symmetric measure space on the half-line.
Lindsay, J. Martin, Das, Bata Krishna
core