Results 101 to 110 of about 535,015 (301)

An Evolutionary Approach to Drug-Design Using Quantam Binary Particle Swarm Optimization Algorithm

, 2012
The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a functional group.
Chowdhury, Arkabandhu, Ghosh, Arnab, Ghosh, Avishek, Hazra, Jubin   +3 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Effects of detraining on functional fitness and lymphocyte subsets in postmenopausal females [PDF]

, 2014
Introduction: Aging leads to declines of functional fitness and regular exercise has been recognized to be beneficial for keeping health and preventing degenerative diseases in older adults.
Chen, Che-Min, Chen, Cheng-Chung, Chien, Li-Hui, Lee, Ting-Ting, Li, Tzai-Li, Wen, Huei-Jhen   +5 more
core   +1 more source

On the Origin of Risk Sensitivity: the Energy Budget Rule Revisited

, 2015
The risk-sensitive foraging theory formulated in terms of the (daily) energy budget rule has been influential in behavioural ecology as well as other disciplines.
Lim, Ik Soo, Parkinson, John, Wittek, Peter   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Corrigendum: Effects of Whole Body Electrostimulation Associated With Body Weight Training on Functional Capacity and Body Composition in Inactive Older People

Frontiers in Physiology, 2021
Alexandre Lopes Evangelista, Angelica Castilho Alonso, Raphael M. Ritti-Dias, Bruna Massaroto Barros, Cleison Rodrigues de Souza, Tiago Volpi Braz, Danilo Sales Bocalini, Julia Maria D'andréa Greve   +7 more
doaj   +3 more sources

Analyzing the Effects of a 12-Week Yoga and Elastic-Band Resistance Training Program on Functional Fitness in Intermediate-Level Male Tennis Athletes: A Randomised Controlled Trial

Physical Education Theory and Methodology
Background. Yoga and elastic-band resistance training (EBRT) are cost-effective methods to enhance physical function, yet their combined effects on competitive young tennis athletes remain underexplored. Objectives.
Prashant Kumar Choudhary, Suchishrava Choudhary, Indri Wulandari, Sohom Saha   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Commentary: Effects of Whole Body Electrostimulation Associated With Body Weight Training on Functional Capacity and Body Composition in Inactive Older People

Frontiers in Physiology, 2021
Alexandre Lopes Evangelista, Angelica Castilho Alonso, Raphael Ritti-Dias, Bruna Massaroto Barros, Cleison Rodrigues de Souza, Tiago Volpi Braz, Danilo Sales Bocalini, Julia Maria D'andréa Greve   +7 more
doaj   +1 more source