Results 71 to 80 of about 535,935 (302)

Early functional improvement after stroke correlates with cardiovascular fitness

open access: yesKaohsiung Journal of Medical Sciences, 2018
Cardiovascular fitness exerts directly beneficial effects on functional and cognitive outcomes in patients of chronic stroke. However, the effect of early rehabilitation on cardiovascular function has not yet been thoroughly examined.
Chun-Kai Chen   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Assessment of the efficiency of cognitive function of people over 65

open access: yesJournal of Education, Health and Sport, 2018
Demographic estimates for Poland indicate that the average life expectancy of the population will increase further over the next decades. Weakness of memory is a physiological phenomenon affecting about 60% of people over 65, whereas the prevalence of ...
Katarzyna Tomaszewska   +2 more
doaj   +3 more sources

Le processus incapacitant au cours du vieillissement : rôle de l’exercice/activité physique

open access: yesBulletins et Mémoires de la Société d’Anthropologie de Paris, 2007
Aging is a phenomenon of increased importance in contemporaneous societies. Although it is well established that physical exercise/activity contributes to maintain functional fitness at optimal levels, physical inactivity is a largely prevalent behaviour
Philipe de Souto Barreto   +1 more
doaj   +1 more source

Natural process – Natural selection [PDF]

open access: yes, 2007
Life is supported by a myriad of chemical reactions. To describe the overall process we have formulated entropy for an open system undergoing chemical reactions.
Annila, Arto
core  

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]

open access: yes, 2019
HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D   +4 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diffusion-based neuromodulation can eliminate catastrophic forgetting in simple neural networks

open access: yes, 2017
A long-term goal of AI is to produce agents that can learn a diversity of skills throughout their lifetimes and continuously improve those skills via experience. A longstanding obstacle towards that goal is catastrophic forgetting, which is when learning
Clune, Jeff, Velez, Roby
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Selection, inheritance, and the evolution of parent-offspring interactions

open access: yes, 2004
Very few studies have examined parent-offspring interactions from a quantitative genetic perspective. We used a cross-fostering design and measured genetic correlations and components of social selection arising from two parental and two offspring ...
Lock, Judith E.   +2 more
core   +1 more source

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