Results 121 to 130 of about 8,902,876 (363)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]
, 2010 The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras +28 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Functional food consumption in Germany: A lifestyle segmentation study [PDF]
Due to increasing health consciousness among consumers, there is an ever‐growing demand for food and beverages with health‐improving components. Not only ‘light’ and low fat products are in demand, but increasingly so‐called well‐being products and food ...
Franz, Annabell, Nowak, Beate
core
Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or not?
Food Research International, 2023 Sara Badawy +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
THE IMPACT OF REGULATION ON THE DEVELOPMENT OF NEW PRODUCTS IN THE FOOD INDUSTRY [PDF]
Paper prepared for presentation at the 8th ICABR International Conference on Agricultural Biotechnology: International Trade and Domestic Production Ravello (Italy), July 8 to 11th, 2004Food industry, Regulation, Innovation, Biotechnology, Organic food ...
Blind, Knut, Menrad, Klaus
core +1 more source
Functional properties of a promissory Dioscorea trifida waxy starch for food innovation [PDF]
, 2010 Starches with low amylose contents generally exhibit good gel clarity, high swelling power and RVA peak viscosity, large breakdown, and high resistance to retrogradation during gel storage, as compared to some other starches with higher amylose contents.
Dufour, Dominique +5 more
core
Integration of functional and traditional food in emerging markets. Regulatory and substantive aspects of yerba mate and quinoa [PDF]
, 2016 Given the rising cost of healthcare, the increase in life expectancy and the wish for a better quality of life, the request for foods and beverages producing a beneficial effect on health has increased worldwide.
Gafare, Claudia Elena +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source