Results 41 to 50 of about 4,923,357 (298)

Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome

Frontiers in Physiology
BackgroundIntestinal barrier dysfunction is increasingly implicated in the pathophysiology of fibromyalgia (FM) and irritable bowel syndrome (IBS), particularly in their comorbid form. Physical capacity (PC) influences systemic inflammation and metabolic
Francesco Russo, Antonella Bianco, Laura Prospero, Gaetana Laselva, Marco Grasso, Benedetta D’Attoma, Nicola Verrelli, Antonia Ignazzi, Isabella Franco, Francesco Goscilo, Claudia Beatrice Bagnato, Anna Ancona, Maria Notarnicola, Michele Linsalata, Giuseppe Riezzo   +14 more
doaj   +1 more source

TRIMEBUTIN IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER FUNCTIONAL GASTROINTESTINAL DISORDERS

Медицинский совет, 2016
Irritable bowel syndrome is seen as a «reference» for understanding pathogenetic essence of functional gastrointestinal disorders. At the basis of functional gastrointestinal disorders are combined morphological and physiological abnormalities associated
D. I. TRUKHAN, I. A. GRISHECHKINA, N. A. BYKHOVTSEV   +2 more
doaj   +1 more source

Development and validation of the korean rome III questionnaire for diagnosis of functional gastrointestinal disorders

, 2018
Alidation studies; Dyspepsia; Functional gastrointestinal disorders; Irritable bowel syndrome ...
정혜경
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The impact of locus of control on somatic and psychological profiles of patients with irritable bowel syndrome engaging in aerobic exercise

Scientific Reports
Irritable bowel syndrome (IBS) is a chronic and recurrent disorder characterized by gastrointestinal (GI) symptoms and psychological disorders. Individuals with an external locus of control (LoC), a personality trait influencing one’s actions and ...
Laura Prospero, Giuseppe Riezzo, Benedetta D’Attoma, Antonia Ignazzi, Antonella Bianco, Isabella Franco, Ritanna Curci, Angelo Campanella, Claudia Beatrice Bagnato, Piero Porcelli, Gianluigi Giannelli, Francesco Russo   +11 more
doaj   +1 more source

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

Frontiers in Pharmacology
Irritable bowel syndrome (IBS) is a complex and multifaceted disorder of the gut-brain interaction. Recent evidence suggests that γ-aminobutyric acid (GABA) may be involved in the development of IBS symptoms.
Christian Lambiase, Christian Lambiase, Francesco Rettura, Francesco Rettura, Francesco Rettura, Giusi Desirè Sciumè, Giusi Desirè Sciumè, Riccardo Tedeschi, Riccardo Tedeschi, Antonio Grosso, Antonio Grosso, Lorenzo Cancelli, Lorenzo Cancelli, Andrea Bottari, Andrea Bottari, Matteo Fornai, Luca Antonioli, Nicola de Bortoli, Nicola de Bortoli, Massimo Bellini, Massimo Bellini   +20 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Association of Psychological Comorbidity with the Number of Functional Gastrointestinal Disorders

International Journal of Body, Mind and Culture, 2016
Background: The overlap of functional gastrointestinal disorders (FGIDs) has been reported in literature. Hence, this study aimed to examine psychological comorbidity with the number of FGIDs.Methods: A total of 4763 individuals in 20 cities across ...
Hamidreza Roohafza, Ali Molaee, Hamid Afshar, Mina Mazaheri, Awat Feizi, Ammar Hassanzadeh-Keshteli, Peyman Adibi   +6 more
doaj   +3 more sources

Divergent intestinal barrier and neuroimmune responses to supervised exercise across fibromyalgia, irritable bowel syndrome, and their comorbidity phenotypes: a prospective interventional study

Frontiers in Physiology
BackgroundFibromyalgia (FM) and irritable bowel syndrome (IBS) are overlapping functional somatic syndromes characterized by gut-brain axis dysregulation and low-grade systemic inflammation.
Antonella Bianco, Francesco Russo, Laura Prospero, Gaetana Laselva, Marco Grasso, Benedetta D’Attoma, Nicola Verrelli, Antonia Ignazzi, Isabella Franco, Elisa Grazioli, Attilio Parisi, Giuseppe Riezzo   +11 more
doaj   +1 more source

Hypersensitivity in functional gastrointestinal disorders [PDF]

Gut, 2002
Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception—that is, its relation to clinical symptoms—remains unclear. Data indicate that sensory dysfunction is associated with altered reflex activity.
openaire   +2 more sources