Results 201 to 210 of about 2,594,564 (358)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Alternative Splicing of Functional Genes in Plant Growth, Development, and Stress Responses. [PDF]

Int J Mol Sci
Liu G, Wang H, Gao H, Yu S, Liu C, Wang Y, Sun Y, Zhang D.   +7 more
europepmc   +1 more source

Functional dissection of dorsal gene isoforms in Eastern honeybee in response to Ascosphaera apis infection

Zang He, Fangji Wang, Chen Xinrui, Li Xiang, Yang Xue, Tan Qinwei, Chen Dafu, Rui Guo, Qiu Jianfeng   +8 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi-omics profiling of Curcuma Wenyujin under salt-alkali stress reveals functional genes and associated metabolites. [PDF]

BMC Plant Biol
Zhang X, Fan R, Pan L, Jiang X, Sun Z, Wu Z, Bao X, Dai L.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Ecotone-Driven Vegetation Transitions Reshape Soil Nitrogen Cycling Functional Genes in Black Soils of Northeast China. [PDF]

Biology (Basel)
Ding J, Wang Y, Yu S.
europepmc   +1 more source

Additional file 13: of Comparative functional genomics analysis of bHLH gene family in rice, maize and wheat

, 2018
Kaifa Wei, Huiqin Chen
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification and Characterization of the <i>Efbzip</i> Gene Family in <i>Erianthus fulvus</i> and Exploration of Functional Genes Involved in Sucrose Metabolism. [PDF]

Genes (Basel)
Zhao C, Nong W, Qian Z, Ding Q, Wang Y, He L, Li F.   +6 more
europepmc   +1 more source