Results 91 to 100 of about 2,526,308 (267)

Dissipative Sturm-Liouville operators with a spectral parameter in the boundary condition on bounded time scales

Electronic Journal of Differential Equations, 2017
In this article we consider a second-order Sturm-Liouville operator with a spectral parameter in the boundary condition on bounded time scales. We construct a selfadjoint dilation of the dissipative Sturm-Liouville operators.
Bilender P. Allahverdiev, Aytekin Eryilmaz, Huseyin Tuna   +2 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Pmf-cpi: assessing drug selectivity with a pretrained multi-functional model for compound-protein interactions. [PDF]

J Cheminform, 2023
Song N, Dong R, Pu Y, Wang E, Xu J, Guo F.   +5 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The systematic aspects of the automation of environmental activities in the oil and gas companies in the Far North

Тонкие химические технологии, 2012
In this article the systematic approach to the automation of environmental activities in the oil and gas companies in the Far North is proposed, and on the basis of this approach the functional model of the system of industrial ecological monitoring was ...
V. I. Ravicovch, M. V. Baukin, L. L. Kapitonova   +2 more
doaj  

Development of an Algorithm for Searching Candidates to Form the Initial Project Team

RUDN Journal of Engineering Research
In this study the authors propose an algorithm for identifying candidates to form the initial project team, such as founders, co-founders, and key participants of any project, organization, or startup.
Anton A. Boykov, Yulia A. Nazarova, Dmitry A. Sementsov, Ilya V. Shishkin, Evgeny A. Malikov, Kirill I. Podkin   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Of precarity and conspiracy: Introducing a socio-functional model of conspiracy beliefs. [PDF]

Br J Soc Psychol, 2023
Adam-Troian J, Chayinska M, Paladino MP, Uluğ ÖM, Vaes J, Wagner-Egger P.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source